Endocrine toxicities of immune checkpoint inhibitors
Immune checkpoint inhibitors (ICIs) are monoclonal antibodies that target two key signalling
pathways related to T cell activation and exhaustion, by binding to and inhibiting cytotoxic T …
pathways related to T cell activation and exhaustion, by binding to and inhibiting cytotoxic T …
Primary hypothyroidism and quality of life
L Hegedüs, AC Bianco, J Jonklaas… - Nature Reviews …, 2022 - nature.com
In the 1970s, treatment with thyroid extract was superseded by levothyroxine, a synthetic l
form of tetraiodothyronine. Since then, no major innovation has emerged for the treatment of …
form of tetraiodothyronine. Since then, no major innovation has emerged for the treatment of …
[HTML][HTML] Evidence-based use of levothyroxine/liothyronine combinations in treating hypothyroidism: a consensus document
Background: Fourteen clinical trials have not shown a consistent benefit of combination
therapy with levothyroxine (LT4) and liothyronine (LT3). Despite the publication of these …
therapy with levothyroxine (LT4) and liothyronine (LT3). Despite the publication of these …
Selenium in thyroid disorders—essential knowledge for clinicians
KH Winther, MP Rayman, SJ Bonnema… - Nature Reviews …, 2020 - nature.com
In the 1990s, selenium was identified as a component of an enzyme that activates thyroid
hormone; since this discovery, the relevance of selenium to thyroid health has been widely …
hormone; since this discovery, the relevance of selenium to thyroid health has been widely …
Thyroid hormone therapy for older adults with subclinical hypothyroidism
Background The use of levothyroxine to treat subclinical hypothyroidism is controversial. We
aimed to determine whether levothyroxine provided clinical benefits in older persons with …
aimed to determine whether levothyroxine provided clinical benefits in older persons with …
[HTML][HTML] Hypothyroidism and depression: a narrative review
SP Nuguru, S Rachakonda, S Sripathi, MI Khan… - Cureus, 2022 - ncbi.nlm.nih.gov
There has been an established relationship between hypothyroidism and depression.
Studies have demonstrated that somatostatin and serotonin influence the hypothalamus …
Studies have demonstrated that somatostatin and serotonin influence the hypothalamus …
Thyroid hormone therapy for hypothyroidism
B Biondi, DS Cooper - Endocrine, 2019 - Springer
The purpose of this article will be to review the basics of thyroid hormone therapy, including
various thyroid hormone formulations, the institution and monitoring of thyroid hormone …
various thyroid hormone formulations, the institution and monitoring of thyroid hormone …
Patient satisfaction and quality of life in hypothyroidism: An online survey by the british thyroid foundation
AL Mitchell, L Hegedüs, M Žarković… - Clinical …, 2021 - Wiley Online Library
Objective Dissatisfaction with treatment and impaired quality of life (QOL) are reported
among people with treated hypothyroidism. We aimed to gain insight into this. Design and …
among people with treated hypothyroidism. We aimed to gain insight into this. Design and …
Association between levothyroxine treatment and thyroid-related symptoms among adults aged 80 years and older with subclinical hypothyroidism
Importance It is unclear whether levothyroxine treatment provides clinically important
benefits in adults aged 80 years and older with subclinical hypothyroidism. Objective To …
benefits in adults aged 80 years and older with subclinical hypothyroidism. Objective To …
Individualized therapy for hypothyroidism: is T4 enough for everyone?
MD Ettleson, AC Bianco - The Journal of Clinical Endocrinology …, 2020 - academic.oup.com
Context It is well recognized that some hypothyroid patients on levothyroxine (LT4) remain
symptomatic, but why patients are susceptible to this condition, why symptoms persist, and …
symptomatic, but why patients are susceptible to this condition, why symptoms persist, and …