Growing evidence suggests that the gut microbiota modulates the efficacy and toxicity of
cancer therapy, most notably immunotherapy and its immune-related adverse effects. The …

The gut microbiota has rapidly emerged as one of the “hallmarks of cancers” and a key
contributor to cancer immunotherapy. Metagenomics profiling has established the link …

Gut-microbiota modulation shows promise in improving immune-checkpoint blockade (ICB)
response; however, precision biomarker-driven, placebo-controlled trials are lacking. We …

For decades, cancer research and treatment focused on the cellular level, viewing cancer as
a genetic disease of cell transformation. In the era of chemotherapy and radiotherapy …

Abstract Purpose of Review This review summarizes recent data linking gut microbiota
composition to ICI outcomes and gut microbiota-specific interventional clinical trials in …

Camu camu (CC) is a prebiotic that selectively stimulates growth and activity of beneficial
gut microbiota. Work in murine models demonstrated that castalagin, the active compound in …

Increasing evidence has proved that microbiota is not only the target of small molecule
drugs but also an underexplored resource for developing small molecule drugs. Meanwhile …

Nature| Vol 607| 21 July 2022| 437© 2022 Springer Nature Li mited. All rights reserved.
trend coincided with an explosion of interest in immunotherapies. These drugs have had …

The human microbiome plays a pivotal role in immune modulation, and its influence on the
development and progression of cancer has gained increasing recognition. Based on the …

Our knowledge of the complex interactions between the gut microbiome and the numerous
mechanisms by which they affect health and illness has greatly increased. Recent evidence …