Efflux-mediated antifungal drug resistance
Fungi cause serious infections in the immunocompromised and debilitated, and the
incidence of invasive mycoses has increased significantly over the last 3 decades. Slow …
incidence of invasive mycoses has increased significantly over the last 3 decades. Slow …
Genomic plasticity of the human fungal pathogen Candida albicans
The genomic plasticity of Candida albicans, a commensal and common opportunistic fungal
pathogen, continues to reveal unexpected surprises. Once thought to be asexual, we now …
pathogen, continues to reveal unexpected surprises. Once thought to be asexual, we now …
Tolerance to Caspofungin in Candida albicans Is Associated with at Least Three Distinctive Mechanisms That Govern Expression of FKS Genes and Cell Wall …
F Yang, L Zhang, H Wakabayashi, J Myers… - Antimicrobial agents …, 2017 - Am Soc Microbiol
Expanding echinocandin use to prevent or treat invasive fungal infections has led to an
increase in the number of breakthrough infections due to resistant Candida species …
increase in the number of breakthrough infections due to resistant Candida species …
Aneuploid Chromosomes Are Highly Unstable during DNA Transformation of Candida albicans
K Bouchonville, A Forche, KES Tang, A Selmecki… - Eukaryotic …, 2009 - Am Soc Microbiol
Candida albicans strains tolerate aneuploidy, historically detected as karyotype alterations
by pulsed-field gel electrophoresis and more recently revealed by array comparative …
by pulsed-field gel electrophoresis and more recently revealed by array comparative …
FKS2 and FKS3 Genes of Opportunistic Human Pathogen Candida albicans Influence Echinocandin Susceptibility
S Suwunnakorn, H Wakabayashi… - Antimicrobial agents …, 2018 - Am Soc Microbiol
Candida albicans, a prevailing opportunistic fungal pathogen of humans, has a diploid
genome containing three homologous FKS genes that are evolutionarily conserved. One of …
genome containing three homologous FKS genes that are evolutionarily conserved. One of …
Multiple genes of Candida albicans influencing echinocandin susceptibility in caspofungin-adapted mutants
SK Sah, S Bhattacharya, A Yadav… - Antimicrobial Agents …, 2022 - Am Soc Microbiol
Candida albicans is an opportunistic human fungal pathogen that causes invasive infections
in immunocompromised individuals. Despite the high anticandidal activity among the …
in immunocompromised individuals. Despite the high anticandidal activity among the …
Chromosome 5 monosomy of Candida albicans controls susceptibility to various toxic agents, including major antifungals
F Yang, A Kravets, G Bethlendy, S Welle… - Antimicrobial agents …, 2013 - Am Soc Microbiol
Candida albicans is a prevailing fungal pathogen with a diploid genome that can adapt to
environmental stresses by losing or gaining an entire chromosome or a large portion of a …
environmental stresses by losing or gaining an entire chromosome or a large portion of a …
The Impact of Gene Dosage and Heterozygosity on the Diploid Pathobiont Candida albicans
SH Liang, RJ Bennett - Journal of Fungi, 2019 - mdpi.com
Candida albicans is a fungal species that can colonize multiple niches in the human host
where it can grow either as a commensal or as an opportunistic pathogen. The genome of C …
where it can grow either as a commensal or as an opportunistic pathogen. The genome of C …
Widespread occurrence of chromosomal aneuploidy following the routine production of Candida albicans mutants
It has come to our attention that approximately 35% of> 100 published microarray datasets,
where transcript levels were compared between two different strains, exhibit some form of …
where transcript levels were compared between two different strains, exhibit some form of …
Genome-Wide DNA Changes Acquired by Candida albicans Caspofungin-Adapted Mutants
J Zuber, SK Sah, DH Mathews, E Rustchenko - Microorganisms, 2023 - mdpi.com
Drugs from the echinocandin (ECN) class are now recommended 'front-line'treatments of
infections caused by a prevailing fungal pathogen, C. albicans. However, the increased use …
infections caused by a prevailing fungal pathogen, C. albicans. However, the increased use …