[HTML][HTML] ME/CFS and Long COVID share similar symptoms and biological abnormalities: road map to the literature

AL Komaroff, WI Lipkin - Frontiers in Medicine, 2023 - frontiersin.org
Some patients remain unwell for months after “recovering” from the acute COVID-19. They
develop persistent fatigue, cognitive problems, headaches, disrupted sleep, myalgias and …

Pathogenesis underlying neurological manifestations of long COVID syndrome and potential therapeutics

A Leng, M Shah, SA Ahmad, L Premraj, K Wildi… - Cells, 2023 - mdpi.com
The development of long-term symptoms of coronavirus disease 2019 (COVID-19) more
than four weeks after primary infection, termed “long COVID” or post-acute sequela of …

SARS-CoV-2 Spike protein induces TLR4-mediated long-term cognitive dysfunction recapitulating post-COVID-19 syndrome in mice

FL Fontes-Dantas, GG Fernandes, EG Gutman… - Cell reports, 2023 - cell.com
Cognitive dysfunction is often reported in patients with post-coronavirus disease 2019
(COVID-19) syndrome, but its underlying mechanisms are not completely understood …

Human pluripotent-stem-cell-derived organoids for drug discovery and evaluation

JJ Vandana, C Manrique, LA Lacko, S Chen - Cell Stem Cell, 2023 - cell.com
Human pluripotent stem cells (hPSCs) and three-dimensional organoids have ushered in a
new era for disease modeling and drug discovery. Over the past decade, significant …

Microglia-containing human brain organoids for the study of brain development and pathology

W Zhang, J Jiang, Z Xu, H Yan, B Tang, C Liu… - Molecular …, 2023 - nature.com
Microglia are resident immune cells in the central nervous system, playing critical roles in
brain development and homeostasis. Increasing evidence has implicated microglia …

Role of SARS-CoV-2 spike-protein-induced activation of microglia and mast cells in the pathogenesis of neuro-COVID

TC Theoharides, D Kempuraj - Cells, 2023 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus
disease 2019 (COVID-19). About 45% of COVID-19 patients experience several symptoms a …

Neurodevelopmental disorders—high-resolution rethinking of disease modeling

K Khodosevich, CM Sellgren - Molecular Psychiatry, 2023 - nature.com
Neurodevelopmental disorders arise due to various risk factors that can perturb different
stages of brain development, and a combinatorial impact of these risk factors programs the …

Human 3D brain organoids: steering the demolecularization of brain and neurological diseases

YK Adlakha - Cell Death Discovery, 2023 - nature.com
Understanding of human brain development, dysfunction and neurological diseases has
remained limited and challenging due to inability to recapitulate human brain-specific …

Orchestration of antiviral responses within the infected central nervous system

A Pavlou, F Mulenge, OL Gern, LM Busker… - Cellular & molecular …, 2024 - nature.com
Many newly emerging and re-emerging viruses have neuroinvasive potential, underscoring
viral encephalitis as a global research priority. Upon entry of the virus into the CNS, severe …

Cortical Grey matter volume depletion links to neurological sequelae in post COVID-19 “long haulers”

TL Rothstein - BMC neurology, 2023 - Springer
Abstract Objective COVID-19 (SARS-CoV-2) has been associated with neurological
sequelae even in those patients with mild respiratory symptoms. Patients experiencing …