Molecular and cellular mechanisms of atrial fibrosis in atrial fibrillation
S Nattel - JACC: Clinical Electrophysiology, 2017 - jacc.org
Atrial fibrillation (AF) is the most common arrhythmia in clinical practice. Atrial fibrosis has
emerged as an important pathophysiological contributor and has been linked to AF …
emerged as an important pathophysiological contributor and has been linked to AF …
The clinical profile and pathophysiology of atrial fibrillation: relationships among clinical features, epidemiology, and mechanisms
Atrial fibrillation (AF) is the most common arrhythmia (estimated lifetime risk, 22%–26%). The
aim of this article is to review the clinical epidemiological features of AF and to relate them to …
aim of this article is to review the clinical epidemiological features of AF and to relate them to …
Novel therapeutic strategies targeting fibroblasts and fibrosis in heart disease
Our understanding of the functions of cardiac fibroblasts has moved beyond their roles in
heart structure and extracellular matrix generation and now includes their contributions to …
heart structure and extracellular matrix generation and now includes their contributions to …
Modulation of Cardiac Arrhythmogenesis by Epicardial Adipose Tissue: JACC State-of-the-Art Review
AC Ernault, VMF Meijborg, R Coronel - Journal of the American College of …, 2021 - jacc.org
Obesity is a significant risk factor for arrhythmic cardiovascular death. Interactions between
epicardial adipose tissue (EAT) and myocytes are thought to play a key role in the …
epicardial adipose tissue (EAT) and myocytes are thought to play a key role in the …
Molecular determinants of cardiac fibroblast electrical function and therapeutic implications for atrial fibrillation
Cardiac fibroblasts account for about 75% of all cardiac cells, but because of their small size
contribute only∼ 10–15% of total cardiac cell volume. They play a crucial role in cardiac …
contribute only∼ 10–15% of total cardiac cell volume. They play a crucial role in cardiac …
[HTML][HTML] Atrial fibrillation: mechanisms, therapeutics, and future directions
J Pellman, F Sheikh - Comprehensive Physiology, 2015 - ncbi.nlm.nih.gov
Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia, affecting 1% to 2% of the
general population. It is characterized by rapid and disorganized atrial activation leading to …
general population. It is characterized by rapid and disorganized atrial activation leading to …
Myocyte-fibroblast communication in cardiac fibrosis and arrhythmias: Mechanisms and model systems
Abstract Development of cardiac fibrosis and arrhythmias is controlled by the activity of and
communication between cardiomyocytes and fibroblasts in the heart. Myocyte-fibroblast …
communication between cardiomyocytes and fibroblasts in the heart. Myocyte-fibroblast …
Mechanosensing dysregulation in the fibroblast: a hallmark of the aging heart
The myofibroblast is a specialized fibroblast that expresses α-smooth muscle actin (α-SMA)
and participates in wound contraction and fibrosis. The fibroblast to myofibroblast transition …
and participates in wound contraction and fibrosis. The fibroblast to myofibroblast transition …
Personalized cardiac computational models: from clinical data to simulation of infarct-related ventricular tachycardia
A Lopez-Perez, R Sebastian, M Izquierdo… - Frontiers in …, 2019 - frontiersin.org
In the chronic stage of myocardial infarction, a significant number of patients develop life-
threatening ventricular tachycardias (VT) due to the arrhythmogenic nature of the remodeled …
threatening ventricular tachycardias (VT) due to the arrhythmogenic nature of the remodeled …
OptoDyCE as an automated system for high-throughput all-optical dynamic cardiac electrophysiology
The improvement of preclinical cardiotoxicity testing, discovery of new ion-channel-targeted
drugs, and phenotyping and use of stem cell-derived cardiomyocytes and other biologics all …
drugs, and phenotyping and use of stem cell-derived cardiomyocytes and other biologics all …