Insulin-like growth factor 2 (IGF2) is a 7.5 kDa mitogenic peptide hormone expressed by liver
and many other tissues. It is three times more abundant in serum than IGF1, but our …

The successful use of high-dose synthetic estrogens to treat postmenopausal metastatic
breast cancer is the first effective 'chemical therapy'proven in clinical trial to treat any cancer …

Curcumin, a yellow polyphenol extracted from the rhizome of turmeric root (Curcuma longa)
has potent anti-cancer properties in many types of tumors with ability to reverse multidrug …

Introduction Globally, hepatocellular carcinoma (HCC) is the sixth most common malignancy
and it has the fourth highest mortality. MicroRNAs play a significant part in biological …

Cirrhosis is the primary risk factor for the development of hepatocellular carcinoma (HCC),
yet the mechanisms by which cirrhosis predisposes to carcinogenesis are poorly …

Background and Aims. Hepatocellular carcinoma (HCC) is the common tumor of the liver.
Unfortunately, most HCC seem to be resistant to conventional chemotherapy and …

Ovarian cancer is one of the most common types of cancer in females and is the leading
cause of death among gynaecological cancers in women worldwide. In the present study …

The tissue inhibitor of metalloproteinase-1 (TIMP-1) is an endogenous inhibitor of matrix
metalloproteinases and potential biomarker of various types of human cancers. However …

Hepatocellular carcinoma (HCC) contributes to 14.8% of all cancer mortality in Egypt, which
has a high prevalence of hepatitis C virus (HCV). We have previously shown alterations in …

miR-let-7a is a tumor suppressor miRNA with reduced expression in most cancers.
Methylation of MIRLET7A3 gene was reported to be the cause of this suppression in several …