With cardiovascular disease being the leading cause of morbidity and mortality worldwide,
effective and cost-efficient therapies to reduce cardiovascular risk are highly needed. Lipids …

Atrial fibrillation is a condition in which control of heart rhythm is taken away from the normal
sinus node pacemaker by rapid activity in different areas within the upper chambers (atria) of …

▪ Abstract Cardiac hypertrophy is the heart's response to a variety of extrinsic and intrinsic
stimuli that impose increased biomechanical stress. While hypertrophy can eventually …

Recent studies call into question the necessity of hypertrophic growth of the heart as a
“compensatory” response to hemodynamic stress. These findings, coupled with recent …

Members of the mitogen‐activated protein kinase (MAPK) cascade such as extracellular
signal‐regulated kinase (ERK), c‐Jun N‐terminal kinase (JNK) and p38 are implicated as …

▪ Abstract This review discusses the rapidly progressing field of cardiomyocyte signal
transduction and the regulation of the hypertrophic response. When stimulated by a wide …

During the past decade, emerging evidence has accumulated of different nuclear
transcription factors in regulation of cardiac development and growth as well as in cardiac …

Cardiovascular diseases, the number 1 cause of death worldwide, are frequently associated
with apoptotic death of cardiac myocytes. Since cardiomyocyte apoptosis is a highly …

Cardiac hypertrophy is a major cause of morbidity and mortality worldwide. The hypertrophic
process is mediated, in part, by small G proteins of the Rho family. We hypothesized that …

Heart failure is one of the leading causes of mortality in the western world and encompasses
a wide spectrum of cardiac pathologies. When the heart experiences extended periods of …