There has been considerable interest in the development of novel compounds with
anticonvulsant, antioxidant, hormone antagonist, analgesic, anti-inflammatory, antiplatelet …

It has been over a century since Carlos Chagas discovered the Trypanosoma cruzi (T. cruzi)
as the causative agent of Chagas disease (CD), a neglected tropical disease with several …

Different compounds have been investigated as potent drugs for trypanosomiasis treatment,
but no new drug has been marketed in the past 3 decades. 4-Thiazolidinone/thiazole as …

The present work reports on the synthesis, anti-Trypanosoma cruzi activities and docking
studies of a novel series of 2-(pyridin-2-yl)-1, 3-thiazoles derived from 2-pyridine …

Abstract A series of novel 2-(5-aminomethylene-4-oxo-2-thioxothiazolidin-3-yl)-3-
phenylpropionic acid ethyl esters has been synthesized. Target compounds were evaluated …

1, 2, 4-Oxadiazole and 1, 2, 3-triazole containing heterocyclic compounds continue to gain
interest in synthesis of chemical entities and exhibit various biological activities as anti …

Chagas disease is one of the most significant health problems in the American continent.
benznidazole (BDZ) and nifurtimox (NFX) are the only drugs approved for treatment and …

In spite of remarkable advances in the knowledge on Trypanosoma cruzi biology, no
medications to treat Chagas disease have been approved in the last 40 years and almost 8 …

Chagas disease is a deadly and centenary neglected disease that is recently surging as a
potential global threat. Approximately 30% of infected individuals develop chronic Chagas …

In previous studies, the compound 3-(bromopropiophenone) thiosemicarbazone was
described as a potent anti-Trypanosoma cruzi and cruzain inhibitor. In view to optimize this …