Glioblastoma multiforme (GBM), the most common and aggressive primary brain tumor, has
a high mortality rate despite extensive efforts to develop new treatments. GBM exhibits both …

Although we have come a long way in our understanding of the signals that drive cancer
growth, and how these signals can be targeted, effective control of this disease remains a …

Glioblastoma (GBM) is a devastating and incurable brain tumour, with a median overall
survival of fifteen months,. Identifying the cell of origin that harbours mutations that drive …

We test the hypothesis that glioblastoma harbors quiescent cancer stem cells that evade anti-
proliferative therapies. Functional characterization of spontaneous glioblastomas from …

The complexity of glioblastoma multiforme, the most common and lethal variant of gliomas,
is reflected by cellular and molecular heterogeneity at both the inter-and intra-tumoural …

Glioblastoma is the most common and lethal primary malignant brain tumor in adults.
Patients die from recurrent tumors that have become resistant to therapy. New strategies are …

Recent advances in genomic technology have led to a better understanding of key
molecular alterations that underlie glioblastoma (GBM). The current WHO-based …

Abstract The N6-methyladenosine (m6A) modification influences various mRNA metabolic
events and tumorigenesis, however, its functions in nonsense-mediated mRNA decay …

The Notch signalling cascade is an evolutionarily conserved pathway that has a crucial role
in regulating development and homeostasis in various tissues. The cellular processes and …

Glioblastoma multiforme is the most common primary malignant brain tumour, with a median
survival of about one year. This poor prognosis is due to therapeutic resistance and tumour …