Breast cancer is a serious health problem worldwide, representing the second cause of
death through malignancies among women in developed countries. Population …

Protein phosphorylation is an important cellular regulatory mechanism as many enzymes
and receptors are activated/deactivated by phosphorylation and dephosphorylation events …

Phosphatidylinositol 3-kinase (PI3K), protein kinase B (PKB/AKT) and mechanistic target of
rapamycin (mTOR)(PAM) pathways play important roles in breast tumorigenesis and confer …

We analysed primary breast cancers by genomic DNA copy number arrays, DNA
methylation, exome sequencing, messenger RNA arrays, microRNA sequencing and …

Breast carcinoma is the leading cause of cancer-related mortality in women worldwide, with
an estimated 1.38 million new cases and 458,000 deaths in 2008 alone. This malignancy …

Activation of the phosphoinositide 3-kinase (PI3K) pathway occurs frequently in breast
cancer. However, clinical results of single-agent PI3K inhibitors have been modest to date. A …

Genomic findings underscore the heterogeneity of head and neck squamous cell carcinoma
(HNSCC). Identification of mutations that predict therapeutic response would be a major …

Somatic PIK3CA mutations are frequently found in solid tumors, raising the hypothesis that
selective inhibition of PI3Kα may have robust efficacy in PIK3CA-mutant cancers while …

Carcinogenesis involves uncontrolled cell growth, which follows the activation of oncogenes
and/or the deactivation of tumor suppression genes. Metastasis requires down-regulation of …

Simple Summary Chemotherapy, radiotherapy and molecularly targeted therapy could
improve the prognosis of colorectal cancer (CRC) patients. Recently, immunotherapy …