Abstract Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic disease and one
of the most common inherited tumor predisposition syndromes, affecting 1 in 3000 …

Ras-specific GTPase-activating proteins (RasGAPs) down-regulate the biological activity of
Ras proteins by accelerating their intrinsic rate of GTP hydrolysis, basically by a transition …

Numerous successful gene-targeted therapies are arising for the treatment of a variety of
rare diseases. At the same time, current treatment options for neurofibromatosis 1 and …

Physiological processes are strictly organized in space and time. However, in cell
physiology research, more attention is given to the question of space rather than to time. To …

To study the role of the neurofibromatosis-1 (NF1) gene in mammalian brain development,
we recently generated mice in which Nf1 gene inactivation occurs in neuroglial progenitor …

Ras leads an important signaling pathway that is deregulated in neurofibromatosis type 1
and malignant peripheral nerve sheath tumor (MPNST). In this study, we show that …

Neurofibromatosis type 1 [NF1] is an autosomal dominant genetic disorder affecting multiple
organs. NF1 is well known for its various clinical manifestations, including café-au-late …

Congenital pseudarthrosis of the tibia (CPT) is a rare congenital bone malformation, which
has a strong relationship with Neurofibromatosis type 1 (NF1). NF1 is an autosomal …

In our previous study we have identified PACAP, VIP and their receptors in rat malignant
peripheral nerve sheath tumor (MPNST) cells, thus showing anti-apoptotic roles. Recently it …

Peripheral nerve sheath tumors from individuals with Neurofibromatosis Type 1 (NF1) are
highly vascular and contain Schwann cells which are deficient in neurofibromin. This study …