The risk for the development of germ cell tumors is an important factor to deal with in the
management of patients with disorders of sex development (DSD). However, this risk is often …

Turner's syndrome is the most common chromosomal abnormality in females, affecting 1:
2,500 live female births. It is a result of absence of an X chromosome or the presence of a …

Turner syndrome is a disorder that has distinct clinical features and has karyotypic
aberrations with loss of critical regions of the X chromosome. Several clinical guidelines on …

Disorders of sex development (DSD), previously referred to as intersex disorders, comprise
a variety of anomalies defined by congenital conditions in which chromosomal, gonadal, or …

Context: Gonadectomy is avoided whenever possible in boys with 45, X/46, XY. However,
no clinical markers are currently available to guide clinicians in predicting gonadal tumor …

Complete androgen insensitivity syndrome (CAIS) is an X-linked recessive genetic disorder
resulting from maternally inherited or de novo mutations involving the androgen receptor …

Male factor infertility accounts for about half the cases of couple infertility and in around 50%
of cases its etiology remains unknown. Molecular genetic techniques have unveiled a …

Despite the identification of an increasing number of candidate genes involved in
spermatogenesis, the armamentarium of diagnostic genetic tests in male infertility remains …

Recent discoveries of many new genes have made it clear that there is more to the human Y
chromosome than a heap of evolutionary debris, hooked up to a sequence that happens to …

Prophylactic gonadectomy in young adult women with complete androgen insensitivity
syndrome (CAIS) to avoid development of an invasive testicular germ cell tumor (TGCT) is …