Neuroticism/negative emotionality is associated with increased reactivity to uncertain threat in the bed nucleus of the stria terminalis, not the amygdala
SE Grogans, J Hur, MG Barstead… - Journal of …, 2024 - jneurosci.org
Neuroticism/negative emotionality (N/NE)—the tendency to experience anxiety, fear, and
other negative emotions—is a fundamental dimension of temperament with profound …
other negative emotions—is a fundamental dimension of temperament with profound …
Suppression of excitatory synaptic transmission in the centrolateral amygdala via presynaptic histamine H3 heteroreceptors
BB Zhang, XY Ling, QY Shen, YX Zhang… - The Journal of …, 2024 - Wiley Online Library
The central histaminergic system has a pivotal role in emotional regulation and psychiatric
disorders, including anxiety, depression and schizophrenia. However, the effect of histamine …
disorders, including anxiety, depression and schizophrenia. However, the effect of histamine …
Dual-specificity protein phosphatase 6 (DUSP6) overexpression reduces amyloid load and improves memory deficits in male 5xFAD mice
Introduction Dual specificity protein phosphatase 6 (DUSP6) was recently identified as a key
hub gene in a causal VGF gene network that regulates late-onset Alzheimer's disease (AD) …
hub gene in a causal VGF gene network that regulates late-onset Alzheimer's disease (AD) …
A shared threat-anticipation circuit is dynamically engaged at different moments by certain and uncertain threat
Temporal dynamics play a central role in models of emotion:“fear” is widely conceptualized
as a phasic response to certain-and-imminent danger, whereas “anxiety” is a sustained …
as a phasic response to certain-and-imminent danger, whereas “anxiety” is a sustained …
Adolescent social anxiety is associated with diminished discrimination of anticipated threat and safety in the bed nucleus of the stria terminalis
Social anxiety, which typically emerges in adolescence, lies on a continuum and, when
extreme, can be devastating, with clear functional impairment evident even at subdiagnostic …
extreme, can be devastating, with clear functional impairment evident even at subdiagnostic …
Connections From the Central Amygdala to the Bed Nucleus of the Stria Terminalis: The Role in Fear Learning
NZ Güngör - Biological Psychiatry, 2024 - biologicalpsychiatryjournal.com
The classical fear conditioning paradigm has been used for decades to investigate the
neural mechanisms of emotional learning. In this paradigm, animals associate two things …
neural mechanisms of emotional learning. In this paradigm, animals associate two things …
[PDF][PDF] Relationship between amygdala and mental disorders
KD Feng, JQ Shen, WY Liu, ZX Zhao, XJ Li - Psychosom Med Res, 2023 - tmrjournals.cn
Mental disorders are a group of diseases with changes in cognition, emotion, behavior, and
other aspects, which may be accompanied by painful experience or functional impairment …
other aspects, which may be accompanied by painful experience or functional impairment …