Immunology of hepatitis B virus and hepatitis C virus infection

B Rehermann, M Nascimbeni - Nature Reviews Immunology, 2005 - nature.com
More than 500 million people worldwide are persistently infected with the hepatitis B virus
(HBV) and/or hepatitis C virus (HCV) and are at risk of developing chronic liver disease …

Adaptive immune responses in acute and chronic hepatitis C virus infection

DG Bowen, CM Walker - Nature, 2005 - nature.com
The hepatitis C virus (HCV) persists in the majority of infected individuals and is a significant
cause of human illness and death globally. Recent studies have yielded important insights …

The antimicrobial peptide LL37 is a T-cell autoantigen in psoriasis

R Lande, E Botti, C Jandus, D Dojcinovic… - Nature …, 2014 - nature.com
Psoriasis is a common T-cell-mediated skin disease with 2–3% prevalence worldwide.
Psoriasis is considered to be an autoimmune disease, but the precise nature of the …

Hepatic T cells and liver tolerance

IN Crispe - Nature Reviews Immunology, 2003 - nature.com
The T-cell biology of the liver is unlike that of any other organ. The local lymphocyte
population is enriched in natural killer (NK) and NKT cells, which might have crucial roles in …

An overview of HCV molecular biology, replication and immune responses

UA Ashfaq, T Javed, S Rehman, Z Nawaz, S Riazuddin - Virology journal, 2011 - Springer
Hepatitis C virus (HCV) causes acute and chronic hepatitis which can eventually lead to
permanent liver damage, hepatocellular carcinoma and death. Currently, there is no vaccine …

Kinetics of the immune response during HBV and HCV infection

A Bertoletti, C Ferrari - Hepatology, 2003 - Elsevier
The innate immune system has a role not only in protecting the host during the initial period
of virus infection, but also in shaping the nature of the adaptive immune response. In this …

Cell-mediated immunity and the outcome of hepatitis C virus infection

NH Shoukry, AG Cawthon, CM Walker - Annu. Rev. Microbiol., 2004 - annualreviews.org
▪ Abstract The hepatitis C virus (HCV) infects approximately three percent of the world's
population. Some individuals resolve the infection spontaneously, but the majority develop …

Hepatitis C virus lacking the hypervariable region 1 of the second envelope protein is infectious and causes acute resolving or persistent infection in chimpanzees

X Forns, R Thimme, S Govindarajan… - Proceedings of the …, 2000 - National Acad Sciences
Persistent infection with hepatitis C virus (HCV) is among the leading causes of chronic liver
disease. Previous studies suggested that genetic variation in hypervariable region 1 (HVR1) …

T cell response in hepatitis C virus infection

C Neumann-Haefelin, HE Blum, FV Chisari… - Journal of Clinical …, 2005 - Elsevier
Hepatitis C virus (HCV) is a hepatotropic RNA virus that causes acute and chronic hepatitis,
liver cirrhosis, and hepatocellular carcinoma. It is widely accepted that cellular immune …

Abnormal Priming of CD4+ T Cells by Dendritic Cells Expressing Hepatitis C Virus Core and E1 Proteins

P Sarobe, JJ Lasarte, N Casares… - Journal of …, 2002 - Am Soc Microbiol
Patients infected with hepatitis C virus (HCV) have an impaired response against HCV
antigens while keeping immune competence for other antigens. We hypothesized that …