Delineating the impact of COVID-19 on antimicrobial resistance: An Indian perspective

PS Seethalakshmi, OJ Charity, T Giakoumis… - Science of the Total …, 2022 - Elsevier
The COVID-19 pandemic has shattered millions of lives globally and continues to be a
challenge to public health due to the emergence of variants of concern. Fear of secondary …

Antifungal development and the urgency of minimizing the impact of fungal diseases on public health

HC de Oliveira, BT Bezerra… - ACS bio & med Chem …, 2022 - ACS Publications
Fungal infections are a major public health problem resulting from the lack of public policies
addressing these diseases, toxic and/or expensive therapeutic tools, scarce diagnostic tests …

A host defense peptide mimetic, brilacidin, potentiates caspofungin antifungal activity against human pathogenic fungi

TF Dos Reis, PA De Castro, RW Bastos… - Nature …, 2023 - nature.com
Fungal infections cause more than 1.5 million deaths a year. Due to emerging antifungal
drug resistance, novel strategies are urgently needed to combat life-threatening fungal …

The anti-virulence activities of the antihypertensive drug propranolol in light of its anti-quorum sensing effects against Pseudomonas aeruginosa and Serratia …

HF Alotaibi, H Alotaibi, KM Darwish, ES Khafagy… - Biomedicines, 2023 - mdpi.com
The development of bacterial resistance is an increasing global concern that requires
discovering new antibacterial agents and strategies. Bacterial quorum sensing (QS) systems …

Repositionable Compounds with Antifungal Activity against Multidrug Resistant Candida auris Identified in the Medicines for Malaria Venture's Pathogen Box

G Wall, N Herrera, JL Lopez-Ribot - Journal of Fungi, 2019 - mdpi.com
Background. Candida auris has spread rapidly around the world as a causative agent of
invasive candidiasis in health care facilities and there is an urgent need to find new options …

NSAIDs as a drug repurposing strategy for biofilm control

C Leão, A Borges, M Simões - Antibiotics, 2020 - mdpi.com
Persistent infections, usually associated with biofilm-producing bacteria, are challenging for
both medical and scientific communities. The potential interest in drug repurposing for …

Synergistic Benefits: Exploring the Anti-Virulence Effects of Metformin/Vildagliptin Antidiabetic Combination against Pseudomonas aeruginosa via Controlling …

MT Khayat, HA Abbas, TS Ibrahim, SS Elbaramawi… - Biomedicines, 2023 - mdpi.com
The repurposing of drugs is one of the most competent strategies for discovering new
antimicrobial agents. Vildagliptin is a dipeptidyl peptidase-4 inhibitor (DPI-4) that is used …

Oxiconazole Potentiates Gentamicin against Gentamicin-Resistant Staphylococcus aureus In Vitro and In Vivo

G Kaul, A Akhir, M Shukla, H Shafi… - Microbiology …, 2023 - Am Soc Microbiol
Amid the mounting burden of multidrug-resistant (MDR) bacterial infections on health care
worldwide, drug repurposing, a time and cost-effective strategy to identify new applications …

Naturally Derived Malabaricone B as a Promising Bactericidal Candidate Targeting Multidrug-Resistant Staphylococcus aureus also Possess Synergistic Interactions …

N Sivadas, G Kaul, A Akhir, M Shukla, MG Govind… - Antibiotics, 2023 - mdpi.com
The emergence of multidrug-resistant (MDR) superbugs underlines the urgent need for
innovative treatment options to tackle resistant bacterial infections. The clinical efficacy of …

Low-Generation Cationic Phosphorus Dendrimers: Novel Approach to Tackle Drug-Resistant S. aureus In Vitro and In Vivo

E Apartsin, A Akhir, G Kaul, D Saxena… - …, 2023 - ACS Publications
The incessant, global increase in antimicrobial resistance (AMR) is a very big challenge for
healthcare systems. AMR is predicted to grow at an alarming pace, with a dramatic increase …