Neuroinflammation in Alzheimer's disease

IG Onyango, GV Jauregui, M Čarná, JP Bennett Jr… - Biomedicines, 2021 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disease associated with human aging.
Ten percent of individuals over 65 years have AD and its prevalence continues to rise with …

Astrocyte senescence and Alzheimer's disease: a review

X Han, T Zhang, H Liu, Y Mi, X Gou - Frontiers in aging neuroscience, 2020 - frontiersin.org
Astrocytes are the largest group of glial cells in the brain and participate in several essential
functions of the central nervous system (CNS). Disruption of their normal physiological …

Protective effects of flavonoids against Alzheimer's disease: pathological hypothesis, potential targets, and structure–activity relationship

J Li, M Sun, X Cui, C Li - International Journal of Molecular Sciences, 2022 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disease with high morbidity and mortality,
for which there is no available cure. Currently, it is generally believed that AD is a disease …

Apelin-13 suppresses neuroinflammation against cognitive deficit in a streptozotocin-induced rat model of Alzheimer's disease through activation of BDNF-TrkB …

H Luo, Y Xiang, X Qu, H Liu, C Liu, G Li… - Frontiers in …, 2019 - frontiersin.org
Alzheimer's disease (AD), a progressive neurodegenerative disease characterized by
impairments of cognitive function as a result of synaptic deficits and neuronal loss, is …

The potential role of human islet amyloid polypeptide in type 2 diabetes mellitus and Alzheimer's diseases

M Alrouji, HM Al-Kuraishy, AI Al-Gareeb… - Diabetology & Metabolic …, 2023 - Springer
Human Islet amyloid polypeptide (hIAPP) from pancreatic β cells in the islet of Langerhans
has different physiological functions including inhibiting the release of insulin and glucagon …

Ellagic acid a multi-target bioactive compound for drug discovery in CNS? A narrative review

S Alfei, F Turrini, S Catena, P Zunin, M Grilli… - European journal of …, 2019 - Elsevier
It is well-known that the health properties attributed to several fruits, herbs, seeds and their
processed foods/beverages are due to an important group of natural polyphenols classified …

A comprehensive review on schisandrin B and its biological properties

MI Nasser, S Zhu, C Chen, M Zhao… - … Medicine and Cellular …, 2020 - Wiley Online Library
Nature is a vast source of bioactive molecules and has provided an active and efficient
reservoir for drug discovery. Among natural compounds, one of the most promising is …

Impact of Helicobacter pylori on Alzheimer's disease: What do we know so far?

M Doulberis, G Kotronis, R Thomann, SA Polyzos… - …, 2018 - Wiley Online Library
Background Helicobacter pylori has changed radically gastroenterologic world, offering a
new concept in patients' management. Over time, more medical data gave rise to diverse …

Increased cysteinyl-tRNA synthetase drives neuroinflammation in Alzheimer's disease

XH Qi, P Chen, YJ Wang, ZP Zhou, XC Liu… - Translational …, 2024 - Springer
Background Microglia-mediated neuroinflammation in Alzheimer's disease (AD) is not only a
response to pathophysiological events, but also plays a causative role in …

[HTML][HTML] Astaxanthin enhances autophagy, amyloid beta clearance and exerts anti-inflammatory effects in in vitro models of Alzheimer's disease-related blood brain …

JA Babalola, M Lang, M George, A Stracke… - Brain Research, 2023 - Elsevier
Defective degradation and clearance of amyloid-β as well as inflammation per se are crucial
players in the pathology of Alzheimer's disease (AD). A defective transport across the blood …