Herbal modulation of P‐glycoprotein
P‐glycoprotein (Pgp) is a 170 kDa phosphorylated glycoprotein encoded by human MDR1
gene. It is responsible for the systemic disposition of numerous structurally and …
gene. It is responsible for the systemic disposition of numerous structurally and …
Mechanisms of clinically relevant drug interactions associated with tacrolimus
U Christians, W Jacobsen, LZ Benet… - Clinical pharmacokinetics, 2002 - Springer
The clinical management of tacrolimus, a macrolide used as immunosuppressant after
transplantation, is complicated by its narrow therapeutic index in combination with inter-and …
transplantation, is complicated by its narrow therapeutic index in combination with inter-and …
Clinical determinants of calcineurin inhibitor disposition: a mechanistic review
T Vanhove, P Annaert, DRJ Kuypers - Drug metabolism reviews, 2016 - Taylor & Francis
The calcineurin inhibitors (CNIs) tacrolimus and cyclosporine are widely used
immunosuppressive drugs characterized by high pharmacokinetic and pharmacodynamic …
immunosuppressive drugs characterized by high pharmacokinetic and pharmacodynamic …
Wine and health: A review
JM Guilford, JM Pezzuto - American Journal of Enology and …, 2011 - Am Soc Enol Viticulture
As indicated by epidemiological studies, regular and moderate wine consumption,
particularly red wine, has been associated with health benefits. Clinical studies and work …
particularly red wine, has been associated with health benefits. Clinical studies and work …
Dietary effects on drug metabolism and transport
RZ Harris, GR Jang, S Tsunoda - Clinical pharmacokinetics, 2003 - Springer
Metabolic food-drug interactions occur when the consumption of a particular food modulates
the activity of a drug-metabolising enzyme system, resulting in an alteration of the …
the activity of a drug-metabolising enzyme system, resulting in an alteration of the …
A mechanistic framework for in vitro–in vivo extrapolation of liver membrane transporters: prediction of drug–drug interaction between rosuvastatin and cyclosporine
Abstract Background and Objectives The interplay between liver metabolising enzymes and
transporters is a complex process involving system-related parameters such as liver blood …
transporters is a complex process involving system-related parameters such as liver blood …
Drug interactions with St John's wort: mechanisms and clinical implications
M Mannel - Drug safety, 2004 - Springer
The purpose of this paper is to review preclinical and clinical evidence relating to drug
interactions with preparations of the medicinal herb St John's wort (Hypericum perforatum) …
interactions with preparations of the medicinal herb St John's wort (Hypericum perforatum) …
Prediction of in vivo drug clearance from in vitro data. I: Impact of inter-individual variability
EM Howgate, K Rowland Yeo, NJ Proctor, GT Tucker… - Xenobiotica, 2006 - Taylor & Francis
The Simcyp® Population-Based ADME Simulator was used to predict median drug
clearances and their associated variance from in vitro data. Fifteen drugs satisfied the entry …
clearances and their associated variance from in vitro data. Fifteen drugs satisfied the entry …
[图书][B] Herbal principles in cosmetics: Properties and mechanisms of action
Authored by a panel of experts in cell physiology, phytochemistry, ethnopharmacology,
applied botany, ethnobotany, and cosmetic science, this book demonstrates the science …
applied botany, ethnobotany, and cosmetic science, this book demonstrates the science …
Drug interaction potential of resveratrol
P Detampel, M Beck, S Krähenbühl… - Drug metabolism …, 2012 - Taylor & Francis
Resveratrol is a naturally occurring polyphenol that is often used as a food supplement.
Many positive health effects, including cardio protection, tumor suppression, and immune …
Many positive health effects, including cardio protection, tumor suppression, and immune …