It has been more than 50 years since the elucidation of the structure of double-helical DNA.
Despite active research and progress in DNA biology and biochemistry, much remains to be …

The λ site‐specific recombination pathway has enjoyed the sequential attentions of
geneticists, biochemists, and structural biologists for more than 50 years. It has proven to be …

The xeroderma pigmentosum C (XPC) complex initiates nucleotide excision repair by
recognizing DNA lesions before recruiting downstream factors. How XPC detects structurally …

Many important biochemical processes occur on the time-scales of nanoseconds and
microseconds. The introduction of the laser temperature-jump (T-jump) to biophysics more …

DNA damage repair starts with the recognition of damaged sites from predominantly normal
DNA. In eukaryotes, diverse DNA lesions from environmental sources are recognized by the …

All cellular organisms and many viruses rely on large, multi-subunit molecular machines,
termed replisomes, to ensure that genetic material is accurately duplicated for transmission …

The mechanical properties of DNA have enabled it to be a structural and sensory element in
many nanotechnology applications. While specific base-pairing interactions and secondary …

Although protein folding is a simple outcome of the underlying thermodynamics, arriving at a
quantitative and predictive understanding of how proteins fold nevertheless poses huge …

The cell–cell signaling process called quorum sensing allows bacteria to control behaviors
in response to changes in population density. In Vibrio harveyi, the master quorum‐sensing …

Integration host factor (IHF) is a prokaryotic protein required for the integration of λ phage
DNA into its host genome. An x-ray crystal structure of the complex shows that IHF binds to …