Proteolysis targeting chimeras (PROTACs) technology has emerged as a novel therapeutic
paradigm in recent years. PROTACs are heterobifunctional molecules that degrade target …

Posttranslational modifications (PTMs), such as phosphorylation, methylation, ubiquitination,
and acetylation, are important in governing protein expression levels. Proteolysis targeting …

Abstract Introduction Natural products (NPs) play a crucial role in the development of
therapeutic drugs. However, it is still highly challenging to identify the targets of NPs …

Tricomponent cobalt (salen)-catalyzed carbofunctionalization of unsaturated substrates by
radical–polar crossover has the potential to streamline access to broad classes of …

There are over 500 human kinases ranging from very well-studied to almost completely
ignored. Kinases are tractable and implicated in many diseases, making them ideal targets …

Targeted protein degradation (TPD) technology is based on a unique pharmacological
mechanism that has profoundly revolutionized medicinal research by overcoming limitations …

The processes used by academic and industrial scientists to discover new drugs have
recently experienced a true renaissance, with many new and exciting techniques being …

The function and significance of RAS proteins in cancer have been widely studied for
decades. In 2013, the National Cancer Institute established the RAS Initiative to explore …

Among the large series of marine natural products (MNPs), sulfur-containing MNPs have
emerged as potential therapeutic agents for the treatment of a range of diseases. Herein, we …

Eukaryotic elongation factor 1A (eEF1A) canonically delivers amino acyl tRNA to the
ribosomal A site during the elongation stage of protein biosynthesis. Yet paradoxically, the …