To define the systemic neuroimmune interactions in health and disease, we recently
suggested immunoception as a term that refers to the existence of bidirectional functional …

Chronic pain (pain lasting for> 3 months) decreases patient quality of life and even
occupational abilities. It can be controlled by treatment, but often persists even after …

Most gastrointestinal diseases and disorders (GIDD) are associated with depression,
anxiety, and cognitive dysfunction. This suggests that shared features of GIDD, particularly …

Background Two‐thirds of patients with migraine without aura (MwoA) complain ictal
cutaneous allodynia (CA), clinical sign of central nociceptive pathway sensitization, and …

Background Treatment of chronic pain is challenged by concurrent anxiety symptoms.
Dexmedetomidine is known to produce sedation, analgesia, and anxiolysis. However, the …

Nowadays, osteoarthritis (OA), a common, multifactorial musculoskeletal disease, is
considered to have a low-grade inflammatory pathogenetic component. Lately …

Chronic osteoarthritis pain is accompanied by several comorbidities whose treatment has
not been completely resolved. The anti-inflammatory, analgesic, and antidepressant effects …

Objectives: Physical exercise therapy is effective for some people with chronic nonspecific
neck pain but not for others. Differences in exercise-induced pain-modulatory responses are …

Osteoarthritis (OA) affects 240 million people worldwide. Neuroimaging has been
increasingly used to investigate brain changes in OA, however, there is considerable …

Objective Several reports in literature have identified sensitization as a possible basis for the
enhanced pain reactions associated with osteoarthritis (OA). The aim of this current …