Selenium is an essential micronutrient with important functions in human health and
relevance to several pathophysiological conditions. The biological effects of selenium are …

A common need for microbial cells is the ability to respond to potentially toxic environmental
insults. Here we review the progress in understanding the response of the yeast …

Sulfur is an essential and quantitatively important element for living organisms. Plants
contain on average approximately 1 g S kg− 1 dry weight (for comparison plants contain …

Redox control of protein function involves oxidation and reduction of amino acid residues,
but the mechanisms and regulators involved are insufficiently understood. Here, we report …

Accumulation of oxidized amino acids, including methionine, has been implicated in aging.
The ability to reduce one of the products of methionine oxidation, free methionine-R …

Methionine (Met) can be oxidized to methionine sulfoxide (MetO), which exist as R-and S-
diastereomers. Present in all three domains of life, methionine sulfoxide reductases (MSR) …

Methionine sulfoxide reductases (Msrs) are thiol-dependent enzymes which catalyze
conversion of methionine sulfoxide to methionine. Three Msr families, MsrA, MsrB, and …

Methionine can be oxidized by reactive oxygen species to a mixture of two diastereomers,
methionine-S-sulfoxide and methionine-R-sulfoxide. Both free amino acid and protein …

Cellular metabolism assembles in a structurally highly conserved, but functionally dynamic
system, known as the metabolic network. This network involves highly active, enzyme …

Significance: Selenium is utilized in the methionine sulfoxide reduction system that occurs in
most organisms. Methionine sulfoxide reductases (Msrs), MsrA and MsrB, are the enzymes …