The role of oxidative stress in atherosclerosis
M Batty, MR Bennett, E Yu - Cells, 2022 - mdpi.com
Atherosclerosis is a chronic inflammatory disease of the vascular system and is the leading
cause of cardiovascular diseases worldwide. Excessive generation of reactive oxygen …
cause of cardiovascular diseases worldwide. Excessive generation of reactive oxygen …
Atrial fibrillation and cardiac fibrosis
C Sohns, NF Marrouche - European heart journal, 2020 - academic.oup.com
The understanding of atrial fibrillation (AF) evolved from a sole rhythm disturbance towards
the complex concept of a cardiomyopathy based on arrhythmia substrates. There is …
the complex concept of a cardiomyopathy based on arrhythmia substrates. There is …
[图书][B] Oxidation and antioxidants in organic chemistry and biology
ET Denisov, IB Afanas' ev - 2005 - taylorfrancis.com
Providing a comprehensive review of reactions of oxidation for different classes of organic
compounds and polymers, and biological processes mediated by free radicals, Oxidation …
compounds and polymers, and biological processes mediated by free radicals, Oxidation …
Mechanisms and consequences of endothelial nitric oxide synthase dysfunction in hypertension
Q Li, JY Youn, H Cai - Journal of hypertension, 2015 - journals.lww.com
Reduced nitric oxide bioavailability contributes to endothelial dysfunction and hypertension.
The endothelial isoform of nitric oxide synthase (eNOS) is responsible for the production of …
The endothelial isoform of nitric oxide synthase (eNOS) is responsible for the production of …
Bone marrow stem cells prevent left ventricular remodeling of ischemic heart through paracrine signaling
R Uemura, M Xu, N Ahmad, M Ashraf - Circulation research, 2006 - Am Heart Assoc
In this study, we hypothesized that bone marrow stem cells (BMSCs) protect ischemic
myocardium through paracrine effects that can be further augmented with preconditioning. In …
myocardium through paracrine effects that can be further augmented with preconditioning. In …
The regulation and pharmacology of endothelial nitric oxide synthase
▪ Abstract Nitric oxide (NO) is a small, diffusible, lipophilic free radical gas that mediates
significant and diverse signaling functions in nearly every organ system in the body. The …
significant and diverse signaling functions in nearly every organ system in the body. The …
Tackling endothelial dysfunction by modulating NOS uncoupling: new insights into its pathogenesis and therapeutic possibilities
R Kietadisorn, RP Juni… - American Journal of …, 2012 - journals.physiology.org
Endothelial nitric oxide synthase (eNOS) serves as a critical enzyme in maintaining vascular
pressure by producing nitric oxide (NO); hence, it has a crucial role in the regulation of …
pressure by producing nitric oxide (NO); hence, it has a crucial role in the regulation of …
eNOS phosphorylation in health and disease
Endothelium plays a fundamental role in maintaining the vascular tone by releasing various
biochemical factors that modulate the contractile and relaxatory behavior of the underlying …
biochemical factors that modulate the contractile and relaxatory behavior of the underlying …
Phosphorylation of threonine 497 in endothelial nitric-oxide synthase coordinates the coupling of L-arginine metabolism to efficient nitric oxide production
MI Lin, D Fulton, R Babbitt, I Fleming, R Busse… - Journal of biological …, 2003 - ASBMB
There is evidence that endothelial nitric-oxide synthase (eNOS) is regulated by reciprocal
dephosphorylation of Thr 497 and phosphorylation of Ser 1179. To examine the …
dephosphorylation of Thr 497 and phosphorylation of Ser 1179. To examine the …
Cardioprotection by intermittent hypoxia conditioning: evidence, mechanisms, and therapeutic potential
RT Mallet, EB Manukhina, SS Ruelas… - American Journal …, 2018 - journals.physiology.org
The calibrated application of limited-duration, cyclic, moderately intense hypoxia-
reoxygenation increases cardiac resistance to ischemia-reperfusion stress. These …
reoxygenation increases cardiac resistance to ischemia-reperfusion stress. These …