The role of oxidative stress in atherosclerosis

M Batty, MR Bennett, E Yu - Cells, 2022 - mdpi.com
Atherosclerosis is a chronic inflammatory disease of the vascular system and is the leading
cause of cardiovascular diseases worldwide. Excessive generation of reactive oxygen …

Atrial fibrillation and cardiac fibrosis

C Sohns, NF Marrouche - European heart journal, 2020 - academic.oup.com
The understanding of atrial fibrillation (AF) evolved from a sole rhythm disturbance towards
the complex concept of a cardiomyopathy based on arrhythmia substrates. There is …

[图书][B] Oxidation and antioxidants in organic chemistry and biology

ET Denisov, IB Afanas' ev - 2005 - taylorfrancis.com
Providing a comprehensive review of reactions of oxidation for different classes of organic
compounds and polymers, and biological processes mediated by free radicals, Oxidation …

Mechanisms and consequences of endothelial nitric oxide synthase dysfunction in hypertension

Q Li, JY Youn, H Cai - Journal of hypertension, 2015 - journals.lww.com
Reduced nitric oxide bioavailability contributes to endothelial dysfunction and hypertension.
The endothelial isoform of nitric oxide synthase (eNOS) is responsible for the production of …

Bone marrow stem cells prevent left ventricular remodeling of ischemic heart through paracrine signaling

R Uemura, M Xu, N Ahmad, M Ashraf - Circulation research, 2006 - Am Heart Assoc
In this study, we hypothesized that bone marrow stem cells (BMSCs) protect ischemic
myocardium through paracrine effects that can be further augmented with preconditioning. In …

The regulation and pharmacology of endothelial nitric oxide synthase

DM Dudzinski, J Igarashi, D Greif… - Annu. Rev. Pharmacol …, 2006 - annualreviews.org
▪ Abstract Nitric oxide (NO) is a small, diffusible, lipophilic free radical gas that mediates
significant and diverse signaling functions in nearly every organ system in the body. The …

Tackling endothelial dysfunction by modulating NOS uncoupling: new insights into its pathogenesis and therapeutic possibilities

R Kietadisorn, RP Juni… - American Journal of …, 2012 - journals.physiology.org
Endothelial nitric oxide synthase (eNOS) serves as a critical enzyme in maintaining vascular
pressure by producing nitric oxide (NO); hence, it has a crucial role in the regulation of …

eNOS phosphorylation in health and disease

GK Kolluru, JH Siamwala, S Chatterjee - Biochimie, 2010 - Elsevier
Endothelium plays a fundamental role in maintaining the vascular tone by releasing various
biochemical factors that modulate the contractile and relaxatory behavior of the underlying …

Phosphorylation of threonine 497 in endothelial nitric-oxide synthase coordinates the coupling of L-arginine metabolism to efficient nitric oxide production

MI Lin, D Fulton, R Babbitt, I Fleming, R Busse… - Journal of biological …, 2003 - ASBMB
There is evidence that endothelial nitric-oxide synthase (eNOS) is regulated by reciprocal
dephosphorylation of Thr 497 and phosphorylation of Ser 1179. To examine the …

Cardioprotection by intermittent hypoxia conditioning: evidence, mechanisms, and therapeutic potential

RT Mallet, EB Manukhina, SS Ruelas… - American Journal …, 2018 - journals.physiology.org
The calibrated application of limited-duration, cyclic, moderately intense hypoxia-
reoxygenation increases cardiac resistance to ischemia-reperfusion stress. These …