The developmental origin of vascular smooth muscle cells (VSMCs) has been increasingly
recognized as a major determinant for regional susceptibility or resistance to vascular …

While inner ear disorders are common, our ability to intervene and recover their sensory
function is limited. In vitro models of the inner ear, like the organoid system, could aid in …

The establishment of cell identity during embryonic development involves the activation of
specific gene expression programmes and is underpinned by epigenetic factors including …

Neural crest (NC) cells are a temporary population of multipotent stem cells that generate a
diverse array of cell types, including craniofacial bone and cartilage, smooth muscle cells …

The peripheral nervous system controls the functions of sensation, movement and motor
coordination of the body. Peripheral nerves can get damaged easily by trauma or …

Schwann cells are glial cells of the peripheral nervous system. They exist in several
subtypes and perform a variety of functions in nerves. Their derivation and culture in vitro are …

Mowat-Wilson syndrome is caused by mutations in ZEB2, with patients exhibiting
characteristics indicative of neural crest (NC) defects. We examined the contribution of ZEB2 …

Several cancer core regulatory circuitries (CRCs) depend on the sustained generation of
DNA accessibility by SWI/SNF chromatin remodelers. However, the window when SWI/SNF …

The neural crest (NC) is a multipotent cell population in vertebrate embryos with
extraordinary migratory capacity. The NC is crucial for vertebrate development and forms a …

During development, the ectoderm is patterned by a combination of BMP and WNT
signaling. Research in model organisms has provided substantial insight into this process; …