Although the biological functions of cell and tissue can be regulated by biochemical factors
(eg, growth factors, hormones), the biophysical effects of materials on the regulation of …

Implant surfaces play important roles in regulating protein adsorption and determining
subsequent cell responses, including cell attachment, proliferation, migration and …

Substrate-exploring functions of filopodia were previously suggested based on cell studies
on flat surfaces, but their role in topography sensing especially within nanofibrillar …

Surface structural modifications at the micrometer and nanometer scales have driven
improved success rates of dental and orthopaedic implants by mimicking the hierarchical …

TiO 2 nanotubes (TNTs) are a promising bone/dental implant surface modification strategy
with enhanced bioactivity and local therapeutic functions. However, inconsistencies related …

Interfacial interactions between cancer cells and surrounding microenvironment involve
complex mechanotransduction mechanisms that are directly associated with tumor invasion …

Abstract Background Members of Rho-associated coiled-coil kinases (ROCKs) are effectors
of Rho family of small GTPases. ROCKs have multiple functions that include regulation of …

Topographical patterning has recently attracted lots of attention in regulating cell fate,
understanding the mechanism of cell–microenvironment interactions, and solving the great …

Surface topography affects cell function and differentiation. It has been previously shown
that rough surfaces can enhance the activation of canonical Wnt signaling, an important …

Bioinert high performance ceramics exhibit detrimental features for implant components with
direct bone contact because of their low osseointegrating capability. We hypothesized that …