The quest to slow ageing through drug discovery

L Partridge, M Fuentealba, BK Kennedy - Nature Reviews Drug …, 2020 - nature.com
Although death is inevitable, individuals have long sought to alter the course of the ageing
process. Indeed, ageing has proved to be modifiable; by intervening in biological systems …

Multifarious beneficial effect of nonessential amino acid, glycine: a review

MA Razak, PS Begum, B Viswanath… - … medicine and cellular …, 2017 - Wiley Online Library
Glycine is most important and simple, nonessential amino acid in humans, animals, and
many mammals. Generally, glycine is synthesized from choline, serine, hydroxyproline, and …

Inflammation, vitamin B6 and related pathways

PM Ueland, A McCann, Ø Midttun, A Ulvik - Molecular aspects of medicine, 2017 - Elsevier
The active form of vitamin B6, pyridoxal 5′-phosphate (PLP), serves as a co-factor in more
than 150 enzymatic reactions. Plasma PLP has consistently been shown to be low in …

Glycine metabolism in animals and humans: implications for nutrition and health

W Wang, Z Wu, Z Dai, Y Yang, J Wang, G Wu - Amino acids, 2013 - Springer
Glycine is a major amino acid in mammals and other animals. It is synthesized from serine,
threonine, choline, and hydroxyproline via inter-organ metabolism involving primarily the …

[图书][B] Amino acids: biochemistry and nutrition

G Wu - 2021 - taylorfrancis.com
Following its predecessor, the second edition of Amino Acids: Biochemistry and Nutrition
presents exhaustive coverage of amino acids in the nutrition, metabolism and health of …

Amino acids and immune function

P Li, YL Yin, D Li, SW Kim, G Wu - British Journal of Nutrition, 2007 - cambridge.org
A deficiency of dietary protein or amino acids has long been known to impair immune
function and increase the susceptibility of animals and humans to infectious disease …

Uptake of nanopolystyrene particles induces distinct metabolic profiles and toxic effects in Caenorhabditis elegans

HM Kim, DK Lee, NP Long, SW Kwon, JH Park - Environmental pollution, 2019 - Elsevier
Nanoplastics are widely used in modern life, for example, in cosmetics and daily use
products, and are attracting concern due to their potential toxic effects on environments. In …

The hepatic microcirculation: mechanistic contributions and therapeutic targets in liver injury and repair

B Vollmar, MD Menger - Physiological reviews, 2009 - journals.physiology.org
The complex functions of the liver in biosynthesis, metabolism, clearance, and host defense
are tightly dependent on an adequate microcirculation. To guarantee hepatic homeostasis …

Electrochemical synthesis of glycine from oxalic acid and nitrate

JE Kim, JH Jang, KM Lee, M Balamurugan… - Angewandte …, 2021 - Wiley Online Library
In manufacturing C− N bond‐containing compounds, it is an important challenge to alternate
the conventional methodologies that utilize reactive substrates, toxic reagents, and organic …

Functions and signaling pathways of amino acids in intestinal inflammation

F He, C Wu, P Li, N Li, D Zhang, Q Zhu… - BioMed research …, 2018 - Wiley Online Library
Intestine is always exposed to external environment and intestinal microorganism; thus it is
more sensitive to dysfunction and dysbiosis, leading to intestinal inflammation, such as …