[HTML][HTML] Molecular mechanisms underlying inherited photoreceptor degeneration as targets for therapeutic intervention

A Bighinati, E Adani, A Stanzani… - Frontiers in Cellular …, 2024 - frontiersin.org
Retinitis pigmentosa (RP) is a form of retinal degeneration characterized by primary
degeneration of rod photoreceptors followed by a secondary cone loss that leads to vision …

New Perspectives in Stem Cell Transplantation and Associated Therapies to Treat Retinal Diseases: From Gene Editing to 3D Bioprinting

G Bovi dos Santos, TH de Lima-Vasconcellos… - Stem Cell Reviews and …, 2024 - Springer
Inherited and non-inherited retinopathies can affect distinct cell types, leading to progressive
cell death and visual loss. In the last years, new approaches have indicated exciting …

[HTML][HTML] Molecular basis for variations in the sensitivity of pathogenic rhodopsin variants to 9-cis-retinal

FJ Roushar, AG McKee, CP Kuntz, JT Ortega… - Journal of Biological …, 2022 - ASBMB
Over 100 mutations in the rhodopsin gene have been linked to a spectrum of retinopathies
that include retinitis pigmentosa and congenital stationary night blindness. Though most of …

[HTML][HTML] Rhodopsin-associated retinal dystrophy: Disease mechanisms and therapeutic strategies

F Zhen, T Zou, T Wang, Y Zhou, S Dong… - Frontiers in …, 2023 - frontiersin.org
Rhodopsin is a light-sensitive G protein-coupled receptor that initiates the phototransduction
cascade in rod photoreceptors. Mutations in the rhodopsin-encoding gene RHO are the …

[HTML][HTML] Galanin receptor 3− A new pharmacological target in retina degeneration

JT Ortega, T Parmar, B Jastrzebska - Pharmacological research, 2023 - Elsevier
The neuropeptide galanin receptor 3 (GALR3) is a class AG protein-coupled receptor
(GPCR) broadly expressed in the nervous system, including the retina. GALR3 is involved in …

Visual fatigue a comprehensive review of mechanisms of occurrence, animal model design and nutritional intervention strategies

H Duan, W Yan - Critical Reviews in Food Science and Nutrition, 2023 - Taylor & Francis
When the eyes work intensively, it is easy to have eye discomfort such as blurred vision,
soreness, dryness, and tearing, that is, visual fatigue. Visual fatigue not only affects work and …

[HTML][HTML] Neural and Müller glial adaptation of the retina to photoreceptor degeneration

HO Leinonen, E Bull, Z Fu - Neural Regeneration Research, 2023 - journals.lww.com
The majority of inherited retinal degenerative diseases and dry age-related macular
degeneration are characterized by decay of the outer retina and photoreceptors, which …

Chromenone derivatives as novel pharmacological chaperones for retinitis pigmentosa-linked rod opsin mutants

JT Ortega, AG McKee, FJ Roushar… - Human Molecular …, 2022 - academic.oup.com
The correct expression of folded, functional rhodopsin (Rho) is critical for visual perception.
However, this seven-transmembrane helical G protein-coupled receptor is prone to …

Sigma 1 receptor activation improves retinal structure and function in the RhoP23H/+ mouse model of autosomal dominant retinitis pigmentosa

SR Barwick, H Xiao, D Wolff, J Wang, E Perry… - Experimental eye …, 2023 - Elsevier
Retinitis pigmentosa (RP) is a group of devastating inherited retinal diseases that leads to
visual impairment and oftentimes complete blindness. Currently no cure exists for RP thus …

视网膜对光感受器变性的神经和Müller 胶质细胞适应

HO Leinonen, E Bull, Z Fu - 中国神经再生研究(英文版), 2023 - sjzsyj.com.cn
The majority of inherited retinal degenerative diseases and dry age-related macular
degeneration are characterized by decay of the outer retina and photoreceptors, which …