Lipases are important industrial enzymes. Most of the lipases operate at lipid–water
interfaces enabled by a mobile lid domain located over the active site. Lid protects the active …

Directed evolution has advanced into a standard industrial “tool” to tailor naturally occurring
proteins for a variety of biotechnological applications, thus enabling product valorization and …

Plastics, including poly (ethylene terephthalate)(PET), possess many desirable
characteristics and thus are widely used in daily life. However, non-biodegradability, once …

The amino acid sequence of a protein affects both its structure and its function. Thus, the
ability to modify the sequence, and hence the structure and activity, of individual proteins in …

The area of biocatalysis itself is in rapid development, fueled by both an enhanced
repertoire of protein engineering tools and an increasing list of solved problems …

Enzymes within a family often catalyze different reactions. In some cases, this variety stems
from different catalytic machinery, but in other cases, the machinery is identical; …

Many computational enzyme design approaches have been developed in recent years that
focus on a reduced set of key enzymatic features. Initial protocols mostly focused on the …

Biocatalysis has undergone a tremendous development in the past few years. A plethora of
methods enable the rather rapid tailored-design of an enzyme for a targeted reaction such …

Enzymes have the potential to catalyse a wide variety of chemical reactions. They are
increasingly being sought as environmentally friendly and cost‐effective alternatives to …

In this review we analyse structure/sequence–function relationships for the superfamily of
PLP-dependent enzymes with special emphasis on class III transaminases. Amine …