Much has been learned since the early 1960s about histone post-translational modifications
(PTMs) and how they affect DNA-templated processes at the molecular level. This …

Cells differentiate and progress through development guided by a dynamic chromatin
landscape that mediates gene expression programmes. During development, mammalian …

The genetic compensation response (GCR) has recently been proposed as a possible
explanation for the phenotypic discrepancies between gene-knockout and gene …

Following fertilization, the two specified gametes must unite to create an entirely new
organism. The genome is initially transcriptionally quiescent, allowing the zygote to be …

The development of animal embryos is initially directed by maternal gene products. Then,
during the maternal-to-zygotic transition (MZT), developmental control is handed to the …

Chromatin, the template for epigenetic regulation, is a highly dynamic entity that is constantly
reshaped during early development and differentiation. Epigenetic modification of chromatin …

The idea that epigenetic determinants such as DNA methylation, histone modifications or
RNA can be passed to the next generation through meiotic products (gametes) is long …

Histone modifications have critical roles in regulating the expression of developmental
genes during embryo development in mammals,. However, genome-wide analyses of …

Polycomb group (PcG) proteins are crucial chromatin regulators that maintain repression of
lineage-inappropriate genes and are therefore required for stable cell fate. Recent advances …

The first major developmental transition in vertebrate embryos is the maternal-to-zygotic
transition (MZT) when maternal mRNAs are degraded and zygotic transcription begins …