Glycomimetics versus multivalent glycoconjugates for the design of high affinity lectin ligands
One could certainly highlight a conceptual resemblance between social interactions as the
basis of societies and civilizations and the ability of molecules to interact in a noncovalent …
basis of societies and civilizations and the ability of molecules to interact in a noncovalent …
Glycopolymer nanobiotechnology
Molecular recognition plays an important role in living systems. 1, 2 Representative
molecular recognitions in living organisms are saccharide− protein, protein− protein, and …
molecular recognitions in living organisms are saccharide− protein, protein− protein, and …
Polymorphic toxin systems: comprehensive characterization of trafficking modes, processing, mechanisms of action, immunity and ecology using comparative …
Background Proteinaceous toxins are observed across all levels of inter-organismal and
intra-genomic conflicts. These include recently discovered prokaryotic polymorphic toxin …
intra-genomic conflicts. These include recently discovered prokaryotic polymorphic toxin …
Common themes in microbial pathogenicity revisited
Bacterial pathogens employ a number of genetic strategies to cause infection and,
occasionally, disease in their hosts. Many of these virulence factors and their regulatory …
occasionally, disease in their hosts. Many of these virulence factors and their regulatory …
Shiga-like toxins are neutralized by tailored multivalent carbohydrate ligands
PI Kitov, JM Sadowska, G Mulvey, GD Armstrong… - Nature, 2000 - nature.com
The diseases caused by Shiga and cholera toxins account for the loss of millions of lives
each year. Both belong to the clinically significant subset of bacterial AB5 toxins consisting …
each year. Both belong to the clinically significant subset of bacterial AB5 toxins consisting …
Organizing multivalency in carbohydrate recognition
C Müller, G Despras, TK Lindhorst - Chemical Society Reviews, 2016 - pubs.rsc.org
The interactions of cell surface carbohydrates as well as of soluble glycoconjugates with
their receptor proteins rule fundamental processes in cell biology. One of the …
their receptor proteins rule fundamental processes in cell biology. One of the …
Mechanisms of bacterial pathogenicity
JW Wilson, MJ Schurr, CL LeBlanc… - Postgraduate …, 2002 - academic.oup.com
Pathogenic bacteria utilise a number of mechanisms to cause disease in human hosts.
Bacterial pathogens express a wide range of molecules that bind host cell targets to facilitate …
Bacterial pathogens express a wide range of molecules that bind host cell targets to facilitate …
Lipid rafts and caveolae as portals for endocytosis: new insights and common mechanisms
RG Parton, AA Richards - Traffic, 2003 - Wiley Online Library
Clathrin‐coated pits and caveolae are two of the most recognizable features of the plasma
membrane of mammalian cells. While our understanding of the machinery regulating and …
membrane of mammalian cells. While our understanding of the machinery regulating and …
Structure and function of the Salmonella Typhi chimaeric A2B5 typhoid toxin
Salmonella enterica serovar Typhi (S. Typhi) differs from most other salmonellae in that it
causes a life-threatening systemic infection known as typhoid fever. The molecular bases for …
causes a life-threatening systemic infection known as typhoid fever. The molecular bases for …
Sortase A: a model for transpeptidation and its biological applications
N Pishesha, JR Ingram… - Annual review of cell and …, 2018 - annualreviews.org
Molecular biologists and chemists alike have long sought to modify proteins with
substituents that cannot be installed by standard or even advanced genetic approaches. We …
substituents that cannot be installed by standard or even advanced genetic approaches. We …