Intron retention has long been an exemplar of regulated splicing with case studies of
individual events serving as models that provided key mechanistic insights into the process …

Epithelial-to-mesenchymal transition (EMT) is associated with metastasis formation as well
as with generation and maintenance of cancer stem cells. In this way, EMT contributes to …

Plants, unlike animals, exhibit a very high degree of plasticity in their growth and
development and employ diverse strategies to cope with the variations during diurnal cycles …

Intron retention (IR) occurs when an intron is transcribed into pre-mRNA and remains in the
final mRNA. We have developed a program and database called IRFinder to accurately …

Intron retention (IR) is a form of alternative splicing that has long been neglected in
mammalian systems although it has been studied for decades in non-mammalian species …

Mass spectrometry-based proteomics now enables the absolute quantification of thousands
of proteins in individual cell types. We used this technology to analyze the dynamic …

Mutations in the RNA-binding protein FUS cause amyotrophic lateral sclerosis (ALS), a
devastating neurodegenerative disease. FUS plays a role in numerous aspects of RNA …

Global transcriptome reprogramming during spermatogenesis ensures timely expression of
factors in each phase of male germ cell differentiation. Spermatocytes and spermatids …

While intron retention (IR) is considered a widely conserved and distinct mechanism of gene
expression control, its regulation is poorly understood. Here we show that DNA methylation …

Intron retention (IR) occurs when a complete and unspliced intron remains in mature mRNA.
An increasing body of literature has demonstrated a major role for IR in numerous biological …