Type 1 diabetes mellitus (T1DM) results from the destruction of pancreatic β-cells that is
mediated by the immune system. Multiple genetic and environmental factors found in …

Type 1 Diabetes (T1D) is one of the most common chronic autoimmune diseases in children.
The disease is characterized by the destruction of beta cells, leading to hyperglycemia, and …

Several immunotherapies have demonstrated endogenous insulin preservation in recent-
onset type 1 diabetes (T1D). We considered the primary results of rituximab, abatacept …

Type 1 diabetes mellitus imposes a significant burden of complications and mortality,
despite important advances in treatment: subjects affected by this disease have also a worse …

Type 1 diabetes (T1D) is a chronic autoimmune disorder that results from the selective
destruction of insulin-producing β-cells in the pancreas. Up to now, the mechanisms …

An increasing body of evidence indicates that bio-energetic metabolism of T cells can be
manipulated to control T cell responses. This potentially finds a field of application in the …

Abstract Type 1 Diabetes (T1D) is an autoimmune disease marked by direct elimination of
insulin-producing β cells by autoreactive T effectors. Recent T1D clinical trials utilizing …

Costimulation serves as a critical checkpoint for T-cell activation, and several genetic
variants affecting costimulatory pathways confer risk for autoimmune diseases. A single …

Hyperglycaemia is a major aetiological factor in the development of diabetic
cardiomyopathy. Excessive hyperglycaemia increases the levels of reactive carbonyl …

Type 1 diabetes (T1D) is an autoimmune disorder in which the body's own immune system
selectively attacks beta cells within pancreatic islets resulting in insufficient insulin …