Targeting Ribonucleases with Small Molecules and Bifunctional Molecules

L Borgelt, P Wu - ACS Chemical Biology, 2023 - ACS Publications
Ribonucleases (RNases) cleave and process RNAs, thereby regulating the biogenesis,
metabolism, and degradation of coding and noncoding RNAs. Thus, small molecules …

Rational design and evaluation of 2-((pyrrol-2-yl) methylene) thiophen-4-ones as RNase L inhibitors

J Hwang, N Haacke, L Borgelt, X Qiu, R Gasper… - European Journal of …, 2023 - Elsevier
Abstract Ribonuclease L (RNase L) plays a crucial role in an antiviral pathway of interferon-
induced innate immunity by degrading RNAs to prevent viral replication. Modulating RNase …

[HTML][HTML] Small-molecule screening of ribonuclease L binders for RNA degradation

L Borgelt, N Haacke, P Lampe, X Qiu, R Gasper… - Biomedicine & …, 2022 - Elsevier
Small molecules targeting the ubiquitous latent ribonuclease (RNase L), which has limited
sequence specificity toward single-stranded RNA substrates, hold great potential to be …

Enzymatic synthesis of vitexin glycosides and their activity

T Xu, Z Fan, J Lou, Q Du, Y Kong, Y Lu, X Wu - RSC advances, 2022 - pubs.rsc.org
Vitexin is an active component of many traditional chinese medicines, and is found in
various plants. The low solubility of vitexin limits its pharmaceutical usage. In this study …

[PDF][PDF] Discovery of small-molecule modulators of the RNA-binding proteins LIN28 and RNase L

L Borgelt - 2023 - d-nb.info
RNA-binding proteins (RBPs) regulate all aspects of RNA biology and metabolism and are
emerging targets for the development of molecular probe compounds and therapeutics for …

[PDF][PDF] Development and evaluation of small molecule-and bifunctional modulators targeting the ribonuclease L for RNA degradation

J Hwang - 2023 - eldorado.tu-dortmund.de
The past four years which I feel were very short but also quite long during my PhD study and
were so precious time to let me learn a lot not only in my scientific life but also in my social …

The making and breaking of tRNAs by ribonucleases

JJH Elder, R Papadopoulos, CK Hayne, RE Stanley - Trends in Genetics, 2024 - cell.com
Ribonucleases (RNases) play important roles in supporting canonical and non-canonical
roles of tRNAs by catalyzing the cleavage of the tRNA phosphodiester backbone. Here, we …