The efficacy and synthetic versatility of asymmetric organocatalysis have contributed
enormously to the field of organic synthesis since the early 2000s. As asymmetric …

This article provides a brief overview of the processes of drug discovery and development.
Our aim is to help scientists whose research may be relevant to drug discovery and/or …

Interest in excitotoxicity expanded following its implication in the pathogenesis of ischemic
brain injury in the 1980s, but waned subsequent to the failure of N-methyl-D-aspartate …

Advances in the neurosciences have placed the field in the position where it is poised to
significantly reduce the burden of nervous system disorders. However, drug discovery …

Neurological disorders are the leading cause of disability and the second largest cause of
death worldwide. Despite significant research efforts, neurology remains one of the most …

Introduction With the exception of the recent accelerated approval of aducanumab, in over
26 years of research and development (R&D) investment in Alzheimer's disease (AD), only …

The accumulation of misfolded proteins (MP s), both unique and common, for different
diseases is central for many chronic degenerative diseases. In certain patients, MP …

Schizophrenia research is providing an increasing number of studies and important insights
into the condition's etiopathogenesis based on genetic, neuropsychological and cranial …

One of the major reasons why central nervous system (CNS)-drug development has been
challenging in the past, is the barriers that prevent substances entering from the blood …

Despite the current availability in the market of over two dozen antiepileptic drugs (AEDs),
about one third of people with epilepsy fail to achieve complete freedom from seizures with …