G-protein–coupled receptors (GPCRs) still offer enormous scope for new therapeutic targets.
Currently marketed agents are dominated by those with activity at aminergic receptors and …

Reproduction is regulated by the hypothalamic-pituitary-gonadal (HPG) axis in vertebrates.
In addition to wealth of knowledge in mammals, recent studies in non-mammalian species …

Neuropeptides and peptide hormones are ancient, widespread signaling molecules that
underpin almost all brain functions. They constitute a broad ligand-receptor network, mainly …

Sexual behavior is essential for the survival of many species. In female rodents, mate
preference and copulatory behavior depend on pheromones and are synchronized with …

Abstract Context: Kisspeptins stimulate GnRH and thus gonadotropin secretion. Kisspeptin-
10 is the minimal kisspeptin sequence with full intrinsic bioactivity, but it has not been …

In humans, as in the other mammals, the neuroendocrine control of reproduction is ensured
by the brain-pituitary gonadotropic axis. Multiple internal and environmental cues are …

Neuropeptides are the most diverse class of chemical modulators in nervous systems. They
contribute to extensive modulation of circuit activity and have profound influences on animal …

Kisspeptin (encoded by the Kiss1 gene) and its receptor, KISS1R (encoded by the Kiss1r
gene), have well-established roles in stimulating reproduction via central actions on …

Mammalian RF-amide peptides are encoded by five different genes and act through five
different G protein-coupled receptors. RF-amide-related peptides-1 and-3, neuropeptides AF …

Excess caloric intake results in increased fat accumulation and an increase in energy
expenditure via diet-induced adaptive thermogenesis; however, the underlying mechanisms …