These parameters were developed by the Joint Task Force on Practice Parameters (JTFPP),
representing the American Academy of Allergy, Asthma & Immunology (AAAAI); the …

Mast cells (MCs), which are granulated tissue-resident cells of hematopoietic lineage,
contribute to vascular homeostasis, innate/adaptive immunity, and wound healing. However …

This evidence‐and consensus‐based guideline was developed following the methods
recommended by Cochrane and the Grading of Recommendations Assessment …

This guideline is the result of a systematic literature review using the 'G rading of R
ecommendations A ssessment, D evelopment and E valuation'(GRADE) methodology and a …

Background Many patients with chronic idiopathic urticaria (also called chronic spontaneous
urticaria) do not have a response to therapy with H1-antihistamines, even at high doses. In …

Background Patients with chronic idiopathic urticaria/chronic spontaneous urticaria
(CIU/CSU) often continue to experience symptoms despite receiving standard-of-care …

ASTERIA I was a 40-week, randomized, double-blind, placebo-controlled study to evaluate
the efficacy and safety of subcutaneous omalizumab as add-on therapy for 24 weeks in …

The monoclonal anti‐immunoglobulin E (IgE) antibody, omalizumab, was the first drug
approved for use in patients with chronic idiopathic/spontaneous urticaria (CIU/CSU) who …

Background Wheal reactions to intradermally injected neuropeptides, such as substance P
(SP) and vasoactive intestinal peptide, are significantly larger and longer lasting in patients …

Idiosyncratic drug reactions are a significant cause of morbidity and mortality for patients;
they also markedly increase the uncertainty of drug development. The major targets are skin …