Many drugs are still prescribed off‐label to the pediatric population. Although off‐label drug
use not supported by high level of evidence is potentially harmful, a comprehensive …

Background In the past two decades, many legislative and regulatory initiatives were taken
globally to improve drug use in children. However, children are still found to be prescribed …

Health-care professionals who prescribe medicines have the professional duty to choose
medicines that are in the best interest of their individual patient, irrespective if that patient is …

In 1907, Indiana passed the world's first involuntary sterilization law based on the theory of
eugenics. In time, more than 30 states and a dozen foreign countries followed suit. Although …

A drug is granted a license for use after a thorough assessment of risks and benefits based
on high‐quality scientific proof of its efficacy and safety. Many drugs that are relevant to …

FOLLOWING US FOOD and Drug Administra-tion (FDA) approval, clinicians may lawfully
prescribe a drug or biologic agent for treatment regimens not specified in the approved …

Background It is common for doctors to engage in clinical innovation—ie to use novel
interventions that differ from standard practice, and that have not yet been shown to be safe …

Off-label prescribing may lead to innovative new uses of old medications, is essential in
such fields as pediatrics, and avoids the lengthy and expensive process of modifying US …

Drug treatment is an essential part of much of psychiatric practice, in patients from a wide
age range, across many diagnostic groups and in a variety of settings. Despite the …

Purpose Off‐label medicines use is a common and sometimes necessary practice in many
populations, with important clinical, ethical and financial consequences, including potential …