The thymus is an evolutionarily conserved organ that supports the development of T cells.
Not only does the thymic environment support the rearrangement and expression of diverse …

B cells have been long studied for their role and function in the humoral immune system.
Apart from generating antibodies and an antibody-mediated memory response against …

The accumulation of senescent cells is a major cause of age-related inflammation and
predisposes to a variety of age-related diseases. However, little is known about the …

High expression of PD-L1 in tumor cells contributes to tumor immune evasion. However,
whether PD-L1 expression in tumor cells is regulated by the availability of nutrients is …

Immunogenic cell death significantly contributes to the success of anti-cancer therapies, but
immunogenicity of different cell death modalities widely varies. Ferroptosis, a form of cell …

DNA mismatch repair deficiency (MMRd) is associated with a high tumor mutational burden
(TMB) and sensitivity to immune checkpoint blockade (ICB) therapy. Nevertheless, most …

Several species of intestinal bacteria have been associated with enhanced efficacy of
checkpoint blockade immunotherapy, but the underlying mechanisms by which the …

Immune checkpoint blockade has provided a paradigm shift in cancer therapy, but the
success of this approach is very variable; therefore, biomarkers predictive of clinical efficacy …

Obesity is a major cancer risk factor, but how differences in systemic metabolism change the
tumor microenvironment (TME) and impact anti-tumor immunity is not understood. Here, we …

Solid tumours are innervated by nerve fibres that arise from the autonomic and sensory
peripheral nervous systems,,,–. Whether the neo-innervation of tumours by pain-initiating …