Eco-friendly and regiospecific intramolecular cyclization reactions of cyano and carbonyl groups in N,N-disubstituted cyanamide

AH Moustafa, WW Ahmed, MF Awad, MO Aboelez… - Molecular Diversity, 2022 - Springer
Eco-friendly, low-cost and high-yielding synthetic route toward imidazoles and oxazoles has
been developed. 1-(4, 6-Dimethylpyrimidin-2-yl)-2-(alkylamino)-1, 5-dihydro-4 H-imidazol-4 …

Novel guanidine derivatives targeting leukemia as selective Src/Abl dual inhibitors: Design, synthesis and anti-proliferative activity

AH Moustafa, AM AboulMagd, AM Ali, A Khodairy… - Bioorganic …, 2024 - Elsevier
A new series of benzene-sulfonamide derivatives 3a-i was designed and synthesized via
the reaction of N-(pyrimidin-2-yl) cyanamides 1a-i with sulfamethazine sodium salt 2 as dual …

Novel Flavanone Naringenin Derivative with Anti-Inflammatory Activity

ROS Souza, LCR Hilgenberg, ACS Pinto… - Journal of the Brazilian …, 2024 - SciELO Brasil
Naringenin is a flavonoid with several biological activities already reported but with few
biological applications in the pharmaceutical field. In this work, a new flavanone, called …

Regiospecific synthesis of N,N'-disubstituted-2-imino-hydantoins derived from cyanamides

MM Khalaf, HM Abd El-Lateef, AH Moustafa… - Synthetic …, 2024 - Taylor & Francis
The present work developed a new simple method and convenient procedure to synthesize
a novel series of 1-(4, 6-dimethylpyrimidin-2-yl)-2-imino-3-arylimidazolidin-4-ones 3. The …

Utility of [4‐(3‐methoxyphenyl) pyrimidin‐2‐yl] cyanamide in synthesis of some heterocyclic compounds

BRM Hussein, A Khodairy - Journal of Heterocyclic Chemistry, 2021 - Wiley Online Library
Abstract N‐[4‐(3‐Methoxyphenyl) pyrimidin‐2‐yl] cyanamide (1) was reacted with
morpholine and respective binuclephilic reagents namely: ethylenediamine, o …