Fibromyalgia and obesity: a comprehensive systematic review and meta-analysis

M D'Onghia, J Ciaffi, L Lisi, L Mancarella, S Ricci… - Seminars in Arthritis and …, 2021 - Elsevier
Introduction Obesity has been associated with several complications, including
musculoskeletal disorders. Aim of the present systematic review was to identify all available …

The association between body fat and musculoskeletal pain: a systematic review and meta-analysis

TP Walsh, JB Arnold, AM Evans, A Yaxley… - BMC musculoskeletal …, 2018 - Springer
Background Obesity and musculoskeletal pain are strongly related, but there is emerging
evidence that body fat, not body weight, may be a better indicator of risk. There is, therefore …

Immune system involvement in specific pain conditions

SK Totsch, RE Sorge - Molecular pain, 2017 - journals.sagepub.com
Chronic pain is a significant problem worldwide and is the most common disability in the
United States. It is well known that the immune system plays a critical role in the …

The role of fat and inflammation in the pathogenesis and management of osteoarthritis

H Urban, CB Little - Rheumatology, 2018 - academic.oup.com
OA is a complex disease involving mechanical, metabolic and inflammatory contributions to
its aetiology. A key risk factor, obesity, is becoming an increasing focus of research due to its …

Associations of body mass index with pain and the mediating role of inflammatory biomarkers in people with hand osteoarthritis

M Gløersen, P Steen Pettersen, T Neogi… - Arthritis & …, 2022 - Wiley Online Library
Objective To examine the association of body mass index (BMI) with pain in people with
hand osteoarthritis (OA), and explore whether this association, if causal, is mediated by …

Evaluation of bodily pain associated with polycystic ovary syndrome: a review of health-related quality of life and potential risk factors

KT Lu, YC Ho, CL Chang, KC Lan, CC Wu, YT Su - Biomedicines, 2022 - mdpi.com
Polycystic ovary syndrome (PCOS) is the most common reproductive disease affecting the
hormone and metabolic status of women. Its associated symptoms are diverse among the …

Intranasal leptin prevents opioid-induced sleep-disordered breathing in obese mice

C Freire, H Pho, LJ Kim, X Wang… - American journal of …, 2020 - atsjournals.org
Respiratory depression is the main cause of morbidity and mortality associated with opioids.
Obesity increases opioid-related mortality, which is mostly related to comorbid obstructive …

Leptin promoter methylation in female patients with painful multisomatoform disorder and chronic widespread pain

J Achenbach, M Rhein, A Glahn, H Frieling, M Karst - Clinical Epigenetics, 2022 - Springer
Background Different functional somatic syndromes (FSS), fibromyalgia (FMS) and other
unexplained painful conditions share many common clinical traits and are characterized by …

Neuroendocrine and neuroimmune mechanisms underlying comorbidity of pain and obesity

DH Zhang, YH Fan, YQ Zhang, H Cao - Life Sciences, 2023 - Elsevier
Pain and obesity, as well as their associated impairments, are major health concerns.
Understanding the relationship between the two is the focus of a growing body of research …

Accelerated epigenetic aging mediates the association between vitamin D levels and knee pain in community-dwelling individuals

LJ Strath, L Meng, A Rani, P Sinha, AJ Johnson… - The journal of nutrition …, 2022 - Springer
Objectives To examine the relationship between Vitamin D status and pain intensity and
disability in individuals with and without knee pain, and to examine the role of epigenetics in …