Post-translational modifications (PTMs) are chemical alterations to a protein following
translation, regulating stability and function. Reversible phosphorylation is an example of an …

Orthotropic liver transplantation is the only established treatment for end-stage liver
diseases. Utilization of hepatocyte transplantation and bio-artificial liver devices as …

In this study, we aimed to elucidate the effects and mechanism of action of valproic acid on
hepatic differentiation from human induced pluripotent stem cell-derived hepatic progenitor …

The use of human induced pluripotent stem (iPS) cells would be of great value for a variety
of applications involving drug development studies. Several reports have been published on …

Understanding and characterizing absorption, metabolism, distribution, and excretion
(ADME) properties of new chemical entities and drug candidates is an integral part of drug …

The coordination of signalling pathways within the cell is vital for normal human
development and post-natal tissue homeostasis. Gene expression and function is therefore …

Accurate prediction of human drug toxicity is a vital part of the drug discovery process.
However, the safety evaluation process is hindered by the availability and quality of primary …

Pluripotent stem cell research has developed over the last fifty years from the study of
embryonic development to a multifaceted discipline that encompasses development …

The liver has a tremendous capacity to regenerate at all developmental stages (for reviews,
see (1-3)). Liver cell mass can be restored even after repeated partial hepatectomies as well …

Human embryonic stem cells (hESCs) hold great promise to provide important new
therapeutic approaches in treating age‐associated diseases and other medical conditions …