[HTML][HTML] Impact of oxidative stress on age-associated decline in oocyte developmental competence
H Sasaki, T Hamatani, S Kamijo, M Iwai… - Frontiers in …, 2019 - frontiersin.org
Reproductive capacity in women starts to decline beyond their mid-30s and pregnancies in
older women result in higher rates of miscarriage with aneuploidy. Age-related decline in …
older women result in higher rates of miscarriage with aneuploidy. Age-related decline in …
Mitochondria in ovarian aging and reproductive longevity
Mitochondrial dysfunction is one of the hallmarks of aging. Consistently mitochondrial DNA
(mtDNA) copy number and function decline with age in various tissues. There is increasing …
(mtDNA) copy number and function decline with age in various tissues. There is increasing …
[HTML][HTML] Therapeutic options for premature ovarian insufficiency: an updated review
Q Huang, S Chen, J Chen, Q Shi, S Lin - Reproductive Biology and …, 2022 - Springer
Primary ovarian insufficiency (POI) is a rare gynecological condition. This disease causes
menstrual disturbances, infertility, and various health problems. Historically, hormone …
menstrual disturbances, infertility, and various health problems. Historically, hormone …
Mitochondrial dysfunction and ovarian aging
I Kasapoğlu, E Seli - Endocrinology, 2020 - academic.oup.com
As women delay childbearing because of demographic and socioeconomic trends,
reproductive aging and ensuing ovarian dysfunction become increasingly more prevalent …
reproductive aging and ensuing ovarian dysfunction become increasingly more prevalent …
Oocyte mitochondria—Key regulators of oocyte function and potential therapeutic targets for improving fertility
The development of oocytes and early embryos is dependent on mitochondrial ATP
production. This reliance on mitochondrial activity, together with the exclusively maternal …
production. This reliance on mitochondrial activity, together with the exclusively maternal …
[HTML][HTML] Age-related changes in Folliculogenesis and potential modifiers to improve fertility outcomes-A narrative review
Reproductive aging is characterized by a decline in oocyte quantity and quality, which is
directly associated with a decline in reproductive potential, as well as poorer reproductive …
directly associated with a decline in reproductive potential, as well as poorer reproductive …
[HTML][HTML] The role of mitochondria in human fertility and early embryo development: what can we learn for clinical application of assessing and improving mitochondrial …
A Podolak, I Woclawek-Potocka, K Lukaszuk - Cells, 2022 - mdpi.com
Mitochondria are well known as 'the powerhouses of the cell'. Indeed, their major role is
cellular energy production driven by both mitochondrial and nuclear DNA. Such a feature …
cellular energy production driven by both mitochondrial and nuclear DNA. Such a feature …
[HTML][HTML] Oxidative stress in reproduction: a mitochondrial perspective
A Almansa-Ordonez, R Bellido, R Vassena… - Biology, 2020 - mdpi.com
Mitochondria are fundamental organelles in eukaryotic cells that provide ATP through
oxidative phosphorylation. During this process, reactive oxygen species (ROS) are …
oxidative phosphorylation. During this process, reactive oxygen species (ROS) are …
[HTML][HTML] Mitofusins: from mitochondria to fertility
S Zhao, N Heng, H Wang, H Wang, H Zhang… - Cellular and Molecular …, 2022 - Springer
Germ cell formation and embryonic development require ATP synthesized by mitochondria.
The dynamic system of the mitochondria, and in particular, the fusion of mitochondria, are …
The dynamic system of the mitochondria, and in particular, the fusion of mitochondria, are …
Increasing ovarian NAD+ levels improve mitochondrial functions and reverse ovarian aging
Q Yang, L Cong, Y Wang, X Luo, H Li, H Wang… - Free Radical Biology …, 2020 - Elsevier
Loss of follicles together with decreased oocyte quality and quantity contribute to age-
associated ovarian senescence and infertility. Although underlying mechanisms for ovarian …
associated ovarian senescence and infertility. Although underlying mechanisms for ovarian …