Evaluation of testicular functions (production of sperm and androgens) is an important
aspect of preclinical safety assessment and testicular toxicity is comparatively far more …

▪ Abstract The luteinizing hormone receptor (LHR) is a member of the subfamily of
glycoprotein hormone receptors within the superfamily of G protein–coupled receptor …

Management and outcome of central precocious puberty Page 1 Clinical Endocrinology (2002)
56, 129–148 © 2002 Blackwell Science Ltd 129 Blackwell Science Ltd Review Treatment of …

The existence of constitutive activity for G protein-coupled receptors (GPCRs) was first
described in 1980s. In 1991, the first naturally occurring constitutively active mutations in …

This short review provides an update on the new information that has become available in
the recent years about mutations and polymorphisms in the genes for gonadotropins and …

Spermatogenesis is a multi-step process of male germ cell (Gc) division and differentiation
which occurs in the seminiferous tubules of the testes under the regulation of gonadotropins …

Precocious puberty is defined as the development of secondary sexual characteristics
before the age of 8 years in girls and 9 years in boys. Gonadotropin-dependent precocious …

BACKGROUND In recent years it became evident that several types of the luteinizing
hormone/choriogonadotrophin receptor (LHCGR) exist. In addition to the classical receptor …

Activating and inactivating mutations in numerous human G protein-coupled receptors
(GPCRs) are associated with a wide range of disease phenotypes. Here we use several …

New information about mutations and polymorphisms in the genes for the gonadotrophins
and their receptors has become available in the last few years. In this short review mutations …