Computational strategies in Klebsiella pneumoniae vaccine design: navigating the landscape of in silico insights.
B Douradinha - Biotechnology Advances, 2024 - Elsevier
The emergence of multidrug-resistant Klebsiella pneumoniae poses a grave threat to global
public health, necessitating urgent strategies for vaccine development. In this context …
public health, necessitating urgent strategies for vaccine development. In this context …
Prediction of epitopes using neural network based methods
In this paper, we describe the methodologies behind three different aspects of the NetMHC
family for prediction of MHC class I binding, mainly to HLAs. We have updated the prediction …
family for prediction of MHC class I binding, mainly to HLAs. We have updated the prediction …
BiPPred: Combined sequence‐and structure‐based prediction of peptide binding to the Hsp70 chaperone BiP
M Schneider, M Rosam, M Glaser… - Proteins: Structure …, 2016 - Wiley Online Library
Substrate binding to Hsp70 chaperones is involved in many biological processes, and the
identification of potential substrates is important for a comprehensive understanding of these …
identification of potential substrates is important for a comprehensive understanding of these …
HLA class I molecular variation and peptide-binding properties suggest a model of joint divergent asymmetric selection
S Buhler, JM Nunes, A Sanchez-Mazas - Immunogenetics, 2016 - Springer
The main function of HLA class I molecules is to present pathogen-derived peptides to
cytotoxic T lymphocytes. This function is assumed to drive the maintenance of an …
cytotoxic T lymphocytes. This function is assumed to drive the maintenance of an …
Positive Selection in CD8+ T-Cell Epitopes of Influenza Virus Nucleoprotein Revealed by a Comparative Analysis of Human and Swine Viral Lineages
HM Machkovech, T Bedford, MA Suchard… - Journal of …, 2015 - Am Soc Microbiol
Numerous experimental studies have demonstrated that CD8+ T cells contribute to immunity
against influenza by limiting viral replication. It is therefore surprising that rigorous statistical …
against influenza by limiting viral replication. It is therefore surprising that rigorous statistical …
KeBABS: an R package for kernel-based analysis of biological sequences
J Palme, S Hochreiter, U Bodenhofer - Bioinformatics, 2015 - academic.oup.com
KeBABS provides a powerful, flexible and easy to use framework for ke rnel-b ased a nalysis
of b iological s equences in R. It includes efficient implementations of the most important …
of b iological s equences in R. It includes efficient implementations of the most important …
Subangstrom accuracy in pHLA-I modeling by Rosetta FlexPepDock refinement protocol
T Liu, X Pan, L Chao, W Tan, S Qu, L Yang… - Journal of chemical …, 2014 - ACS Publications
Flexible peptides binding to human leukocyte antigen (HLA) play a key role in mediating
human immune responses and are also involved in idiosyncratic adverse drug reactions …
human immune responses and are also involved in idiosyncratic adverse drug reactions …
Prediction and identification of mouse cytotoxic T lymphocyte epitopes in Ebola virus glycoproteins
S Wu, T Yu, X Song, S Yi, L Hou, W Chen - Virology Journal, 2012 - Springer
Abstract Background Ebola viruses (EBOVs) cause severe hemorrhagic fever with a high
mortality rate. At present, there are no licensed vaccines or efficient therapies to combat …
mortality rate. At present, there are no licensed vaccines or efficient therapies to combat …
PeptX: using genetic algorithms to optimize peptides for MHC binding
B Knapp, V Giczi, R Ribarics, W Schreiner - BMC bioinformatics, 2011 - Springer
Background The binding between the major histocompatibility complex and the presented
peptide is an indispensable prerequisite for the adaptive immune response. There is a …
peptide is an indispensable prerequisite for the adaptive immune response. There is a …
In-silico discovery of cancer-specific peptide-HLA complexes for targeted therapy
A Dhanik, J R. Kirshner, D MacDonald, G Thurston… - BMC …, 2016 - Springer
Abstract Background Major Histocompatibility Complex (MHC) or Human Leukocyte Antigen
(HLA) Class I molecules bind to peptide fragments of proteins degraded inside the cell and …
(HLA) Class I molecules bind to peptide fragments of proteins degraded inside the cell and …