The immune system is a fascinating world of cells, soluble factors, interacting cells, and
tissues, all of which are interconnected. The highly complex nature of the immune system …

Ubiquitylation is an essential post-translational modification that regulates intracellular
signalling networks by triggering proteasomal substrate degradation, changing the activity of …

Rheumatoid arthritis (RA) is a highly heritable complex disease with unknown etiology. Multi-
ancestry genetic research of RA promises to improve power to detect genetic signals, fine …

To define the cell populations that drive joint inflammation in rheumatoid arthritis (RA), we
applied single-cell RNA sequencing (scRNA-seq), mass cytometry, bulk RNA sequencing …

Fine-mapping aims to identify causal variants impacting complex traits. We propose
PolyFun, a computationally scalable framework to improve fine-mapping accuracy by …

Sjögren's disease is a complex autoimmune disease with twelve established susceptibility
loci. This genome-wide association study (GWAS) identifies ten novel genome-wide …

We report the largest and most diverse genetic study of type 1 diabetes (T1D) to date
(61,427 participants), yielding 78 genome-wide-significant (P< 5× 10− 8) regions, including …

Autoimmunity and autoinflammation arise from aberrant immunological and inflammatory
responses toward self-components, contributing to various autoimmune diseases and …

RA is a chronic systemic inflammatory disease that primarily affects the small joints of the
hands and feet, and results in a mean reduction in life expectancy of 3–10 years. RA is a …

Gastric cancer is a deadly disease and remains the third leading cause of cancer-related
death worldwide. The 5-year overall survival rate of patients with early-stage localized …