Why is placentation abnormal in preeclampsia?
SJ Fisher - American journal of obstetrics and gynecology, 2015 - Elsevier
The causes of preeclampsia remain one of the great medical mysteries of our time. This
syndrome is thought to occur in 2 stages with abnormal placentation leading to a maternal …
syndrome is thought to occur in 2 stages with abnormal placentation leading to a maternal …
Cell-surface proteomics for the identification of novel therapeutic targets in cancer
Introduction: Cancer is the second most common cause of death worldwide and its
heterogeneity complicates therapy. Standard cytotoxic regiments disrupt rapidly dividing …
heterogeneity complicates therapy. Standard cytotoxic regiments disrupt rapidly dividing …
Unsupervised placental gene expression profiling identifies clinically relevant subclasses of human preeclampsia
K Leavey, SJ Benton, D Grynspan, JC Kingdom… - …, 2016 - Am Heart Assoc
Preeclampsia (PE) is a complex, hypertensive disorder of pregnancy, demonstrating
considerable variability in maternal symptoms and fetal outcomes. Unfortunately, prior …
considerable variability in maternal symptoms and fetal outcomes. Unfortunately, prior …
Widespread DNA hypomethylation at gene enhancer regions in placentas associated with early-onset pre-eclampsia
Pre-eclampsia is a serious complication of pregnancy that can affect both maternal and fetal
outcomes. Early-onset pre-eclampsia (EOPET) is a severe form of pre-eclampsia that is …
outcomes. Early-onset pre-eclampsia (EOPET) is a severe form of pre-eclampsia that is …
[HTML][HTML] Large scale aggregate microarray analysis reveals three distinct molecular subclasses of human preeclampsia
Background Preeclampsia (PE) is a life-threatening hypertensive pathology of pregnancy
affecting 3–5% of all pregnancies. To date, PE has no cure, early detection markers, or …
affecting 3–5% of all pregnancies. To date, PE has no cure, early detection markers, or …
[HTML][HTML] Extensive shift in placental transcriptome profile in preeclampsia and placental origin of adverse pregnancy outcomes
One in five pregnant women suffer from gestational complications, prevalently driven by
placental malfunction. Using RNASeq, we analyzed differential placental gene expression in …
placental malfunction. Using RNASeq, we analyzed differential placental gene expression in …
[HTML][HTML] Enabling pregnant women and their physicians to make informed medication decisions using artificial intelligence
L Davidson, MR Boland - Journal of Pharmacokinetics and …, 2020 - Springer
The role of artificial intelligence (AI) in healthcare for pregnant women. To assess the role of
AI in women's health, discover gaps, and discuss the future of AI in maternal health. A …
AI in women's health, discover gaps, and discuss the future of AI in maternal health. A …
[HTML][HTML] Placental secretome characterization identifies candidates for pregnancy complications
Alterations in maternal physiological adaptation during pregnancy lead to complications,
including abnormal birthweight and gestational diabetes. Maternal adaptations are driven by …
including abnormal birthweight and gestational diabetes. Maternal adaptations are driven by …
Igf2 deletion alters mouse placenta endocrine capacity in a sexually dimorphic manner
BRL Aykroyd, SJ Tunster… - Journal of …, 2020 - joe.bioscientifica.com
The placenta regulates materno-fetal nutrient transfer and secretes hormones that enable
maternal physiological support of the pregnancy. In mice, these functions are performed by …
maternal physiological support of the pregnancy. In mice, these functions are performed by …
Placental transcriptome in development and pathology: expression, function, and methods of analysis
The placenta is the essential organ of mammalian pregnancy and errors in its development
and function are associated with a wide range of human pathologies of pregnancy. Genome …
and function are associated with a wide range of human pathologies of pregnancy. Genome …