Targeting proliferating cell nuclear antigen (PCNA) as an effective strategy to inhibit tumor cell proliferation
M Cardano, C Tribioli, E Prosperi - Current cancer drug targets, 2020 - ingentaconnect.com
Targeting highly proliferating cells is an important issue for many types of aggressive tumors.
Proliferating Cell Nuclear Antigen (PCNA) is an essential protein that participates in a variety …
Proliferating Cell Nuclear Antigen (PCNA) is an essential protein that participates in a variety …
Status update in the use of cell-penetrating peptides for the delivery of macromolecular therapeutics
K Kurrikoff, B Vunk, Ü Langel - Expert Opinion on Biological …, 2021 - Taylor & Francis
Introduction In this review, recent developments and applications with cell-penetrating
peptides (CPP) are discussed. CPPs are widely used tools for the delivery of various …
peptides (CPP) are discussed. CPPs are widely used tools for the delivery of various …
MicroRNAs and their big therapeutic impacts: delivery strategies for cancer intervention
C Holjencin, A Jakymiw - Cells, 2022 - mdpi.com
Three decades have passed from the initial discovery of a microRNA (miRNA) in
Caenorhabditis elegans to our current understanding that miRNAs play essential roles in …
Caenorhabditis elegans to our current understanding that miRNAs play essential roles in …
ATX-101, a cell-penetrating protein targeting PCNA, can be safely administered as intravenous infusion in patients and shows clinical activity in a Phase 1 study
CR Lemech, G Kichenadasse, JP Marschner… - Oncogene, 2023 - nature.com
Abstract Proliferating Cell Nuclear Antigen (PCNA) is a highly conserved protein essential
for DNA replication, repair and scaffold functions in the cytosol. Specific inhibition of PCNA …
for DNA replication, repair and scaffold functions in the cytosol. Specific inhibition of PCNA …
PCNA regulates primary metabolism by scaffolding metabolic enzymes
LM Røst, SB Ræder, C Olaisen, CK Søgaard… - Oncogene, 2023 - nature.com
The essential roles of proliferating cell nuclear antigen (PCNA) as a scaffold protein in DNA
replication and repair are well established, while its cytosolic roles are less explored. Two …
replication and repair are well established, while its cytosolic roles are less explored. Two …
ETNK1 mutations induce a mutator phenotype that can be reverted with phosphoethanolamine
Recurrent somatic mutations in ETNK1 (Ethanolamine-Kinase-1) were identified in several
myeloid malignancies and are responsible for a reduced enzymatic activity. Here, we …
myeloid malignancies and are responsible for a reduced enzymatic activity. Here, we …
Recent CPP-based applications in medicine
K Kurrikoff, Ü Langel - Expert opinion on drug delivery, 2019 - Taylor & Francis
Introduction: Cell-penetrating peptides (CPP) offer versatile tools for the field of drug delivery
and development of macromolecular therapeutics. These tools have matured into …
and development of macromolecular therapeutics. These tools have matured into …
ATX-101, a peptide targeting PCNA, has antitumor efficacy alone or in combination with radiotherapy in murine models of human glioblastoma
GL Gravina, A Colapietro, A Mancini, A Rossetti… - Cancers, 2022 - mdpi.com
Simple Summary PCNA is an interesting target for cancertreatment due to its essential
activities in DNA replication and repair and its recently discovered regulatory roles in cellular …
activities in DNA replication and repair and its recently discovered regulatory roles in cellular …
[图书][B] CPP, cell-penetrating peptides
Ü Langel - 2019 - Springer
The genesis of cell-penetrating peptide research (CPP; also known as prote/peptide
transduction domains, PTD, or Trojan peptides) was born from the publication of two parallel …
transduction domains, PTD, or Trojan peptides) was born from the publication of two parallel …
[HTML][HTML] Cell-penetrating peptides as part of therapeutics used in cancer research
M Matijass, I Neundorf - Medicine in Drug Discovery, 2021 - Elsevier
Peptides have gained more and more interest as therapeutics for different fields of medical
indications. Built up via a peptide bond from naturally occurring amino acids they stand out …
indications. Built up via a peptide bond from naturally occurring amino acids they stand out …