Emergence of SARS-CoV-2 Omicron (B. 1.1. 529) variant, salient features, high global health concerns and strategies to counter it amid ongoing COVID-19 pandemic

R Khandia, S Singhal, T Alqahtani, MA Kamal… - Environmental …, 2022 - Elsevier
Since the appearance in the late of December 2019, SARS-CoV-2 is rapidly evolving and
mutating continuously, giving rise to various variants with variable degrees of infectivity and …

The impact of evolving SARS-CoV-2 mutations and variants on COVID-19 vaccines

G McLean, J Kamil, B Lee, P Moore, TF Schulz, A Muik… - MBio, 2022 - Am Soc Microbiol
The emergence of several new variants of severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) in recent months has raised concerns around the potential impact on …

[HTML][HTML] Neutralizing immunity in vaccine breakthrough infections from the SARS-CoV-2 Omicron and Delta variants

V Servellita, AM Syed, MK Morris, N Brazer, P Saldhi… - Cell, 2022 - cell.com
Virus-like particle (VLP) and live virus assays were used to investigate neutralizing immunity
against Delta and Omicron SARS-CoV-2 variants in 259 samples from 128 vaccinated …

A self-assembled trimeric protein vaccine induces protective immunity against Omicron variant

C He, J Yang, W Hong, Z Chen, D Peng, H Lei… - Nature …, 2022 - nature.com
The recently emerged Omicron (B. 1.1. 529) variant has rapidly surpassed Delta to become
the predominant circulating SARS-CoV-2 variant, given the higher transmissibility rate and …

[HTML][HTML] Multiple sclerosis therapies differentially affect SARS-CoV-2 vaccine–induced antibody and T cell immunity and function

JJ Sabatino Jr, K Mittl, WM Rowles, K McPolin… - JCI insight, 2022 - ncbi.nlm.nih.gov
BACKGROUND Vaccine-elicited adaptive immunity is a prerequisite for control of SARS-
CoV-2 infection. Multiple sclerosis (MS) disease-modifying therapies (DMTs) differentially …

SARS‐CoV‐2 Omicron and its current known unknowns: A narrative review

TTB Le, T Vasanthakumaran… - Reviews in Medical …, 2023 - Wiley Online Library
The emergence of the SARS‐CoV‐2 Omicron variant (B. 1.1. 529) has created great global
distress. This variant of concern shows multiple sublineages, importantly B. 1.1. 529.1 (BA …

A SARS-CoV-2 variant elicits an antibody response with a shifted immunodominance hierarchy

AJ Greaney, TN Starr, RT Eguia, AN Loes… - PLoS …, 2022 - journals.plos.org
Many SARS-CoV-2 variants have mutations at key sites targeted by antibodies. However, it
is unknown if antibodies elicited by infection with these variants target the same or different …

[HTML][HTML] Role of the humoral immune response during COVID-19: guilty or not guilty?

M Yaugel-Novoa, T Bourlet, S Paul - Mucosal Immunology, 2022 - Elsevier
Systemic and mucosal humoral immune responses are crucial to fight respiratory viral
infections in the current pandemic of COVID-19 caused by the SARS-CoV-2 virus. During …

[HTML][HTML] Humoral and Cellular Immune Responses of COVID-19 vaccines against SARS-Cov-2 Omicron variant: a systemic review

Z Chen, Y Zhang, M Wang, MS Islam… - … Journal of Biological …, 2022 - ncbi.nlm.nih.gov
Abstract Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has undergone
multiple mutations since its emergence, and its latest variant, Omicron (B. 1.1. 529), is the …

[HTML][HTML] Impact of SARS-CoV-2 exposure history on the T cell and IgG response

R Keeton, MB Tincho, A Suzuki, N Benede… - Cell Reports …, 2023 - cell.com
Multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exposures, from
infection or vaccination, can potently boost spike antibody responses. Less is known about …