Notch signaling controls cell fate decisions including during development and stem cell
renewal and differentiation in many postnatal tissues. Increasing evidence suggests that the …

The Delta-Notch pathway is an evolutionarily conserved signaling pathway which controls a
broad range of developmental processes including cell fate determination, terminal …

Hematopoietic stem cells (HSCs) underlie the production of blood and immune cells for the
lifetime of an organism. In vertebrate embryos, HSCs arise from the unique …

The appearance of molecular differences between arterial and venous endothelial cells
before circulation suggests that genetic factors determine these cell types. We find that …

Heart valve anomalies are some of the most common congenital heart defects, yet neither
the genetic nor the epigenetic forces guiding heart valve development are well understood …

Several vertebrates display the ability to regenerate parts of their body after amputation.
During this process, differentiated cells reenter the cell cycle and proliferate to generate a …

Mechanosensory hair cells within the zebrafish lateral line spontaneously regenerate after
aminoglycoside-induced death. Exposure of 5-d-old larvae to 400 μm neomycin for 1 h …

The Alagille Syndrome (AGS) is a heritable disorder affecting the liver and other organs.
Causative dominant mutations in human Jagged 1 have been identified in most AGS …

Teeth arise from sequential and reciprocal interactions between the oral epithelium and the
underlying cranial neural crest‐derived mesenchyme. Their formation involves a precisely …

Hematopoietic stem cells (HSC s) require multiple molecular inputs for proper specification,
including activity of the Notch signaling pathway. A requirement for the Notch1 and …