Mendelian randomization
Mendelian randomization (MR) is a term that applies to the use of genetic variation to
address causal questions about how modifiable exposures influence different outcomes …
address causal questions about how modifiable exposures influence different outcomes …
A selective review of negative control methods in epidemiology
Abstract Purpose of Review Negative controls are a powerful tool to detect and adjust for
bias in epidemiological research. This paper introduces negative controls to a broader …
bias in epidemiological research. This paper introduces negative controls to a broader …
Strengthening the reporting of observational studies in epidemiology using mendelian randomisation (STROBE-MR): explanation and elaboration
VW Skrivankova, RC Richmond, BAR Woolf… - bmj, 2021 - bmj.com
Mendelian randomisation (MR) studies allow a better understanding of the causal effects of
modifiable exposures on health outcomes, but the published evidence is often hampered by …
modifiable exposures on health outcomes, but the published evidence is often hampered by …
Instrumental variable methods for causal inference
A goal of many health studies is to determine the causal effect of a treatment or intervention
on health outcomes. Often, it is not ethically or practically possible to conduct a perfectly …
on health outcomes. Often, it is not ethically or practically possible to conduct a perfectly …
Using natural experiments to evaluate population health interventions: new Medical Research Council guidance
Natural experimental studies are often recommended as a way of understanding the health
impact of policies and other large scale interventions. Although they have certain …
impact of policies and other large scale interventions. Although they have certain …
Surgery versus conservative treatment for traumatic acute subdural haematoma: a prospective, multicentre, observational, comparative effectiveness study
TA van Essen, HF Lingsma, D Pisică, RD Singh… - The lancet …, 2022 - thelancet.com
Background Despite being well established, acute surgery in traumatic acute subdural
haematoma is based on low-grade evidence. We aimed to compare the effectiveness of a …
haematoma is based on low-grade evidence. We aimed to compare the effectiveness of a …
Conducting real-world evidence studies on the clinical outcomes of diabetes treatments
S Schneeweiss, E Patorno - Endocrine Reviews, 2021 - academic.oup.com
Abstract Real-world evidence (RWE), the understanding of treatment effectiveness in clinical
practice generated from longitudinal patient-level data from the routine operation of the …
practice generated from longitudinal patient-level data from the routine operation of the …
Intensity-modulated radiation therapy, proton therapy, or conformal radiation therapy and morbidity and disease control in localized prostate cancer
NC Sheets, GH Goldin, AM Meyer, Y Wu, YK Chang… - Jama, 2012 - jamanetwork.com
Context There has been rapid adoption of newer radiation treatments such as intensity-
modulated radiation therapy (IMRT) and proton therapy despite greater cost and limited …
modulated radiation therapy (IMRT) and proton therapy despite greater cost and limited …
Confounding in observational studies based on large health care databases: problems and potential solutions–a primer for the clinician
M Nørgaard, V Ehrenstein… - Clinical …, 2017 - Taylor & Francis
Population-based health care databases are a valuable tool for observational studies as
they reflect daily medical practice for large and representative populations. A constant …
they reflect daily medical practice for large and representative populations. A constant …
Impact of rehabilitation on outcomes in patients with ischemic stroke: a nationwide retrospective cohort study in Japan
Background and Purpose—We aimed to examine the concurrent effects of timing and
intensity of rehabilitation on improving activities of daily living (ADL) among patients with …
intensity of rehabilitation on improving activities of daily living (ADL) among patients with …