[HTML][HTML] limma powers differential expression analyses for RNA-sequencing and microarray studies
Abstract limma is an R/Bioconductor software package that provides an integrated solution
for analysing data from gene expression experiments. It contains rich features for handling …
for analysing data from gene expression experiments. It contains rich features for handling …
Aging of hematopoietic stem cells
G de Haan, SS Lazare - Blood, The Journal of the American …, 2018 - ashpublications.org
Hematopoietic stem cells (HSCs) ensure a balanced production of all blood cells throughout
life. As they age, HSCs gradually lose their self-renewal and regenerative potential, whereas …
life. As they age, HSCs gradually lose their self-renewal and regenerative potential, whereas …
[PDF][PDF] Intratumoral Tcf1+ PD-1+ CD8+ T cells with stem-like properties promote tumor control in response to vaccination and checkpoint blockade immunotherapy
I Siddiqui, K Schaeuble, V Chennupati, SAF Marraco… - Immunity, 2019 - cell.com
Checkpoint blockade mediates a proliferative response of tumor-infiltrating CD8+ T
lymphocytes (TILs). The origin of this response has remained elusive because chronic …
lymphocytes (TILs). The origin of this response has remained elusive because chronic …
[HTML][HTML] Robust hyperparameter estimation protects against hypervariable genes and improves power to detect differential expression
One of the most common analysis tasks in genomic research is to identify genes that are
differentially expressed (DE) between experimental conditions. Empirical Bayes (EB) …
differentially expressed (DE) between experimental conditions. Empirical Bayes (EB) …
Mitochondrial arginase-2 is essential for IL-10 metabolic reprogramming of inflammatory macrophages
JK Dowling, R Afzal, LJ Gearing… - Nature …, 2021 - nature.com
Mitochondria are important regulators of macrophage polarisation. Here, we show that
arginase-2 (Arg2) is a microRNA-155 (miR-155) and interleukin-10 (IL-10) regulated protein …
arginase-2 (Arg2) is a microRNA-155 (miR-155) and interleukin-10 (IL-10) regulated protein …
Aberrations of EZH2 in Cancer
A Chase, NCP Cross - Clinical cancer research, 2011 - AACR
Control of gene expression is exerted at a number of different levels, one of which is the
accessibility of genes and their controlling elements to the transcriptional machinery …
accessibility of genes and their controlling elements to the transcriptional machinery …
Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)
Trimethylation of histone H3 on lysine 27 (H3K27me3) is a repressive posttranslational
modification mediated by the histone methyltransferase EZH2. EZH2 is a component of the …
modification mediated by the histone methyltransferase EZH2. EZH2 is a component of the …
IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity
Abstract Interleukin-1 receptor 8 (IL-1R8, also known as single immunoglobulin IL-1R-
related receptor, SIGIRR, or TIR8) is a member of the IL-1 receptor (ILR) family with distinct …
related receptor, SIGIRR, or TIR8) is a member of the IL-1 receptor (ILR) family with distinct …
Epigenetic control of adult stem cell function
A Avgustinova, SA Benitah - Nature reviews Molecular cell biology, 2016 - nature.com
Mammalian embryonic development is a tightly regulated process that, from a single zygote,
produces a large number of cell types with hugely divergent functions. Distinct cellular …
produces a large number of cell types with hugely divergent functions. Distinct cellular …
Hematopoiesis
MA Rieger, T Schroeder - Cold Spring Harbor …, 2012 - cshperspectives.cshlp.org
Enormous numbers of adult blood cells are constantly regenerated throughout life from
hematopoietic stem cells through a series of progenitor stages. Accessibility, robust …
hematopoietic stem cells through a series of progenitor stages. Accessibility, robust …